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Cinnamaldehyde Targets Tlr-4 and Inflammatory Mediators in Acetic-Acid Induced Ulcerative Colitis Model Publisher



Momtaz S1, 2, 3 ; Navabakhsh M4 ; Bakouee N4 ; Dehnamaki M4 ; Rahimifard M2 ; Baeeri M2 ; Abdollahi A5 ; Abdollahi M2 ; Farzaei MH6, 7 ; Abdolghaffari AH1, 2, 3, 4
Authors
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Authors Affiliations
  1. 1. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Tehran, Iran
  2. 2. Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), and Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  3. 3. Gastrointestinal Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  4. 4. Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  5. 5. Department of Pathology, Imam Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  7. 7. Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Biologia Published:2021


Abstract

Cinnamon and its bioactive ingredients such as cinnamaldehyde (CA), with broad pharmacological profiles, are important parts of daily diet in many cultures. Moreover, there are plenty motivating patents on efficacy of nutritional phytochemicals as novel anti-inflammatory drugs in patients with inflammatory bowel disease (IBD). This study intended to evaluate the effects of CA on inflammatory biomarkers in acetic acid-induced colitis rats. Colitis was induced in all animals, except in sham group, using acetic acid (4%). Following colitis induction, in 3 groups, CA was administrated orally at 2, 4 and 8 mg/kg/day for 2 days (once a day). Other groups were defined as the control (only treated with acetic acid), sham group (normal saline), and a standard group (Dexamethasone). To evaluate the inflammation sites, macroscopic and microscopic markers were assessed. Tissue concentrations of interleukin (IL)-6 and tumor necrosis factor-alpha (TNF)-α, were assessed by ELISA assay kits, while myeloperoxidase (MPO) was measured spectrophotometrically. The mRNA expression of toll like receptor (TLR)-4 in colon tissue was assessed by Real time-PCR. CA at 4 mg/kg/day and 8 mg/kg/day significantly improved microscopic and macroscopic manifestations of colitis tissues. TNF-α, MPO, and IL-6 levels were significantly lower in CA treated groups at all the concentrations tested (P < 0.001). CA at 4 and 8 mg/kg/day significantly downregulated the mucosal gene expression of TLR-4. CA attenuated experimental colitis by means of colitis symptoms, reduction in inflammation cytokines, decline of neutrophil infiltration, and suppression of TLR-4 expression in acetic acid-induced colitis. CA improved colitis in animal model through suppression of inflammatory parameters and downregulation of TLR-4 mRNA expression. © 2021, Slovak Academy of Sciences.
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