Early Childhood Exposure to Short Periods of Sevoflurane Is Not Associated With Later, Lasting Cognitive Deficits

Early Childhood Exposure to Short Periods of Sevoflurane Is Not Associated With Later, Lasting Cognitive Deficits Publisher Pubmed

Poor Zamany Nejat Kermany M¹ ; Roodneshin F¹ ; Ahmadi Dizgah N¹ ; Gerami E² ; Riahi E³

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1. Anesthesiology Department, Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Ophthalmology Department, Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Physiology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Paediatric Anaesthesia Published:2016

Abstract

Background: A detrimental effect of commonly used anesthetics on the neurodevelopmental and behavioral parameters has long been shown in young animals subjected to early childhood anesthesia. Epidemiologic studies suggest the possibility of a modestly elevated risk of adverse neurodevelopmental outcomes in children exposed to anesthesia during early childhood. However, these results are still preliminary and inconclusive. Aim: To further elucidate the probability of occurrence of such adverse outcomes, we evaluated cognitive performance of children who underwent general anesthesia early in their childhood. Method: One hundred and fifteen children aged 5‒16 years with established glaucoma were included in the study. Of these, 68 children had a history of at least one general anesthesia with sevoflurane before age 3. Phonemic and semantic verbal fluency, and forward and backward digit span tests were performed to evaluate cognitive function in the study subjects. Results: The two-way anova revealed that all these variables showed significant changes in various age groups, but they were comparable among subjects with no, single, or multiple childhood anesthesia. Conclusion: It can be concluded that brief periods of anesthesia with single anesthetic sevoflurane may be safe for children under age 3. © 2016 John Wiley & Sons Ltd

Style	Citing Format
MLA	Poor Zamany Nejat Kermany M, et al.. "Early Childhood Exposure to Short Periods of Sevoflurane Is Not Associated With Later, Lasting Cognitive Deficits." Paediatric Anaesthesia, vol. 26, no. 10, 2016, pp. 1018-1025.
APA	Poor Zamany Nejat Kermany M, Roodneshin F, Ahmadi Dizgah N, Gerami E, Riahi E (2016). Early Childhood Exposure to Short Periods of Sevoflurane Is Not Associated With Later, Lasting Cognitive Deficits. Paediatric Anaesthesia, 26(10), 1018-1025.
Chicago	Poor Zamany Nejat Kermany M, Roodneshin F, Ahmadi Dizgah N, Gerami E, Riahi E. "Early Childhood Exposure to Short Periods of Sevoflurane Is Not Associated With Later, Lasting Cognitive Deficits." Paediatric Anaesthesia 26, no. 10 (2016): 1018-1025.
Harvard	Poor Zamany Nejat Kermany M et al. (2016) 'Early Childhood Exposure to Short Periods of Sevoflurane Is Not Associated With Later, Lasting Cognitive Deficits', Paediatric Anaesthesia, 26(10), pp. 1018-1025.
Vancouver	Poor Zamany Nejat Kermany M, Roodneshin F, Ahmadi Dizgah N, Gerami E, Riahi E. Early Childhood Exposure to Short Periods of Sevoflurane Is Not Associated With Later, Lasting Cognitive Deficits. Paediatric Anaesthesia. 2016;26(10):1018-1025.
BibTex	@article{ author = {Poor Zamany Nejat Kermany M and Roodneshin F and Ahmadi Dizgah N and Gerami E and Riahi E}, title = {Early Childhood Exposure to Short Periods of Sevoflurane Is Not Associated With Later, Lasting Cognitive Deficits}, journal = {Paediatric Anaesthesia}, volume = {26}, number = {10}, pages = {1018-1025}, year = {2016} }
RIS	TY - JOUR AU - Poor Zamany Nejat Kermany M AU - Roodneshin F AU - Ahmadi Dizgah N AU - Gerami E AU - Riahi E TI - Early Childhood Exposure to Short Periods of Sevoflurane Is Not Associated With Later, Lasting Cognitive Deficits JO - Paediatric Anaesthesia VL - 26 IS - 10 SP - 1018 EP - 1025 PY - 2016 ER -

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