Challenges of Endocrine Therapy in Breast Cancer Publisher



Mansouri S¹ ; Teymourzadeh A¹ ; Farahmand L¹ ; Majidzadeha K² Show Affiliations
Source: Cancer Genetics and Psychotherapy Published:2017

Abstract

This chapter provides evidences on the magnitude of endocrine therapy in the treatment of breast cancer patients and also discusses challenges in endocrine therapy as well as reviewing recent literature on psychotherapy in the management of adverse effect of endocrine therapy. At first, there is a quick review on the role of estrogen in the breast cancer development which was followed by a brief data on the significance of endocrine therapy. Secondly, the major challenges in endocrine therapy such as non-adherent patients during the course of endocrine therapy, endocrine therapy failure especially Tamoxifen and Letrozole resistance and finally adverse effects of endocrine therapy will be discussed in the rest of chapter. Resistance to the endocrine therapy will be explained in details to elucidate the molecular mechanisms underlying this phenomenon. Finally, the recent evidences on the administration of psychotherapy to modulate the adverse effect of endocrine therapy briefly mentioned. © Springer International Publishing AG 2017. All rights reserved.