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The High Frequency of Pik3ca Mutations in Iranian Breast Cancer Patients Publisher Pubmed



Azizi Tabesh G1 ; Izadi P1 ; Fereidooni F2 ; Emami Razavi AN2 ; Tavakkoly Bazzaz J1
Authors
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Authors Affiliations
  1. 1. Medical Genetics Department, Medical School, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Iran National Tumor Bank, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Cancer Investigation Published:2017


Abstract

In breast cancer, somatic mutations of PIK3CA oncogene are common. We investigated the mutational status of exons 9 and 20 of the PIK3CA gene by polymerase chain reaction and direct sequencing in 80 breast tumors, and observed that 45% of these contained PIK3CA mutations in the mentioned exons. These mutations were found more in progesterone receptor positive and Her2– tumors, but this association did not reach a statistically significant level. Also, we observed a significant association between PIK3CA mutations and low-grade tumors. In our study, PIK3CA mutations were related to good and moderate prognosis in breast cancer patients. © 2017 Taylor & Francis Group, LLC.