The High Frequency of Pik3ca Mutations in Iranian Breast Cancer Patients

The High Frequency of Pik3ca Mutations in Iranian Breast Cancer Patients Publisher Pubmed

Azizi Tabesh G¹ ; Izadi P¹ ; Fereidooni F² ; Emami Razavi AN² ; Tavakkoly Bazzaz J¹

Source: Cancer Investigation Published:2017

Abstract

In breast cancer, somatic mutations of PIK3CA oncogene are common. We investigated the mutational status of exons 9 and 20 of the PIK3CA gene by polymerase chain reaction and direct sequencing in 80 breast tumors, and observed that 45% of these contained PIK3CA mutations in the mentioned exons. These mutations were found more in progesterone receptor positive and Her2– tumors, but this association did not reach a statistically significant level. Also, we observed a significant association between PIK3CA mutations and low-grade tumors. In our study, PIK3CA mutations were related to good and moderate prognosis in breast cancer patients. © 2017 Taylor & Francis Group, LLC.

Related Docs

1. Correlation Between Important Genes of Mtor Pathway (Pi3k and Kit) in Iranian Women With Sporadic Breast Cancer, Medical Journal of the Islamic Republic of Iran (2018)

Style	Citing Format
MLA	Azizi Tabesh G, et al.. "The High Frequency of Pik3ca Mutations in Iranian Breast Cancer Patients." Cancer Investigation, vol. 35, no. 1, 2017, pp. 36-42.
APA	Azizi Tabesh G, Izadi P, Fereidooni F, Emami Razavi AN, Tavakkoly Bazzaz J (2017). The High Frequency of Pik3ca Mutations in Iranian Breast Cancer Patients. Cancer Investigation, 35(1), 36-42.
Chicago	Azizi Tabesh G, Izadi P, Fereidooni F, Emami Razavi AN, Tavakkoly Bazzaz J. "The High Frequency of Pik3ca Mutations in Iranian Breast Cancer Patients." Cancer Investigation 35, no. 1 (2017): 36-42.
Harvard	Azizi Tabesh G et al. (2017) 'The High Frequency of Pik3ca Mutations in Iranian Breast Cancer Patients', Cancer Investigation, 35(1), pp. 36-42.
Vancouver	Azizi Tabesh G, Izadi P, Fereidooni F, Emami Razavi AN, Tavakkoly Bazzaz J. The High Frequency of Pik3ca Mutations in Iranian Breast Cancer Patients. Cancer Investigation. 2017;35(1):36-42.
BibTex	@article{ author = {Azizi Tabesh G and Izadi P and Fereidooni F and Emami Razavi AN and Tavakkoly Bazzaz J}, title = {The High Frequency of Pik3ca Mutations in Iranian Breast Cancer Patients}, journal = {Cancer Investigation}, volume = {35}, number = {1}, pages = {36-42}, year = {2017} }
RIS	TY - JOUR AU - Azizi Tabesh G AU - Izadi P AU - Fereidooni F AU - Emami Razavi AN AU - Tavakkoly Bazzaz J TI - The High Frequency of Pik3ca Mutations in Iranian Breast Cancer Patients JO - Cancer Investigation VL - 35 IS - 1 SP - 36 EP - 42 PY - 2017 ER -

Science Communicator Platform

Authors

Abstract