Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evaluation of Pentraxin-3 and Interleukin-6 Levels in Serum and Gingival Crevicular Fluid in Patients With Generalized Periodontitis and Periodontal Health Controls Before and After Scaling and Root Planing Publisher



Yaghobee S1, 2 ; Hasannia S3 ; Hamidzadeh F4 ; Tahbaz SV5 ; Shahmohammadi R2 ; Poursafar F6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Dental Implant Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Periodontology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  4. 4. Department of Endodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Periodontology, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Department of Periodontology, School of Dentistry, Babol University of Medical Sciences, Babol, Iran

Source: Frontiers in Dentistry Published:2025


Abstract

Objectives: Pentraxin-3 (PTX3) and interleukin-6 (IL-6) are two of the most important inflammatory cytokines produced by cells in periodontal tissues. The present study aims to evaluate the levels of PTX3 and IL-6 in serum and gingival crevicular fluid (GCF) in patients with generalized periodontitis stages II and III, grades A and B, and periodontal health individuals before and after scaling and root planing (SRP). Materials and Methods: In this study, 22 patients with periodontitis (12 males and 10 females) and 22 periodontal health controls (11 males and 11 females) were selected. All patients underwent full-mouth SRP. Serum and GCF samples were collected before and one month after SRP. PTX3 and IL-6 levels in serum and GCF samples were evaluated by enzyme-linked immunosorbent assay. Data analysis was performed using Mann-Whitney U and Wilcoxon tests (P<0.05). Results: Serum levels of PTX3 were significantly higher in the periodontitis group than the controls (P<0.05). GCF PTX3 levels and serum and GCF IL-6 levels were not significantly different between the groups. Furthermore, this study did not show any significant changes in the levels of these cytokines before and after SRP. Conclusion: Among the studied cytokines and media, only serum PTX3 levels showed a significant difference between periodontitis patients and healthy controls and could serve as a diagnostic marker of periodontal inflammation. SRP did not affect the levels of these cytokines, suggesting that other inflammatory factors may be involved in disease process. However, additional longitudinal prospective studies are needed to confirm these results. © 2025 The Authors. Published by Tehran University of Medical Sciences.