Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Differences in Fatty Acid Profiles and Desaturation Indices of Abdominal Subcutaneous Adipose Tissue Between Pregnant Women With and Without Pcos Publisher Pubmed



Emami N1 ; Alizadeh A2 ; Moini A3, 4, 5 ; Yaghmaei P1 ; Shahhosseini M6, 7, 8
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Biology, Faculty of Science, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
  3. 3. Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
  4. 4. Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Gynecology and Obstetrics, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
  7. 7. Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
  8. 8. Department of Cell and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran

Source: Adipocyte Published:2020


Abstract

The objective was to determine the differences in fatty acid (FA) profiles in subcutaneous adipose tissue (AT) between pregnant women with polycystic ovary syndrome (PCOS) and those without PCOS. FA profiles of AT samples from 13 PCOS and 32 non-PCOS, all of whom underwent caesarean section were compared using gas chromatography. Age and BMI in the two groups were similar. Twenty-one FAs were detected and the total saturated FA percentage of experimental groups was similar. While the total monounsaturated FA (MUFA) (p < 0.0004) and desaturase index (18:1 cis-9/18:0; p < 0.03) were higher in PCOS women than non-PCOS women, total polyunsaturated FA (PUFA) was lower in PCOS than non-PCOS women (p < 0.004). Docosahexaenoic acid level of the two groups was similar while α-linolenic acid and eicosapentaenoic acid levels were significantly (p < 0.05) lower in PCOS. Total trans-FA, C18:1 t9 and C18:2t were lower in PCOS women (p < 0.05). These results indicate differences in desaturase index, MUFA and PUFA, especially n-3 FA in AT between age and BMI-matched pregnant PCOS and non-PCOS pregnant subjects. Further studies are warranted to replicate these findings and to investigate potential changes in these profiles in non-pregnant PCOS women. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
1. Differences in Gene Expression of Enzymes Involved in Branched-Chain Amino Acid Metabolism of Abdominal Subcutaneous Adipose Tissue Between Pregnant Women With and Without Pcos, Taiwanese Journal of Obstetrics and Gynecology (2021)
2. Fatty Acids in Subcutaneous Adipose Tissue of Pregnant Women With and Without Polycystic Ovary Syndrome Are Associated With Genes Related to Steroidogenesis: A Case-Control Study, International Journal of Fertility and Sterility (2023)
3. Differences in Expression of Genes Related to Steroidgenesis in Abdominal Subcutaneous Adipose Tissue of Pregnant Women With and Without Pcos; a Case Control Study, BMC Pregnancy and Childbirth (2021)
4. Nutrients As Novel Therapeutic Approaches for Metabolic Disturbances in Polycystic Ovary Syndrome, EXCLI Journal (2016)
Experts (# of related papers)
View all Related Experts
Ashraf Moini (3)
Mohammad Reza Mohajeri Tehrani (1)