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Lessons From the Embryo: An Unrejected Transplant and a Benign Tumor Publisher Pubmed



Rezalotfi A1, 2, 3 ; Vrynas AV4 ; Dehghanian M5 ; Rezaei N2, 6, 7, 8
Authors
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Authors Affiliations
  1. 1. Department of Stem Cells and Developmental Biology, Cell Sciences Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
  2. 2. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  4. 4. Department of Bioengineering, Imperial College London, London, United Kingdom
  5. 5. Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran
  6. 6. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Children’s Medical Center Hospital, Dr. Qarib St, Keshavarz Blvd, Tehran, 14194, Iran

Source: Stem Cell Reviews and Reports Published:2021


Abstract

Embryogenesis is regarded the ‘miracle of life’, yet numerous aspects of this process are not fully understood. As the embryo grows in the mother’s womb, immune components, stem cells and microenvironmental cues cooperate among others to promote embryonic development. Evidently, these key players are frequently associated with transplantation failure and tumor growth. While the fields of transplantation and cancer biology do not overlap, both can be viewed from the perspective of an embryo. As an ‘unrejected transplant’ and a ‘benign tumor’, lessons from embryonic development may reveal features of transplants and tumors that have been overlooked. Therefore, eavesdropping at these natural complex events during pregnancy may inspire more durable approaches to arrest transplant rejection or cancer progression. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
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