Biology-Oriented Drug Synthesis (Biods) Approach Towards Synthesis of Ciprofloxacin-Dithiocarbamate Hybrids and Their Antibacterial Potential Both in Vitro and in Silico

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Biology-Oriented Drug Synthesis (Biods) Approach Towards Synthesis of Ciprofloxacin-Dithiocarbamate Hybrids and Their Antibacterial Potential Both in Vitro and in Silico Publisher Pubmed

Esfahani EN¹ ; Mohammadikhanaposhtani M² ; Rezaei Z³ ; Valizadeh Y³ ; Rajabnia R⁴ ; Bagheri M⁵ ; Bandarian F¹ ; Faramarzi MA⁶ ; Samadi N⁷ ; Amini MR⁸ ; Mahdavi M⁸ ; Larijani B⁸

Source: Chemistry and Biodiversity Published:2018

Abstract

A novel series of ciprofloxacin-dithiocarbamate hybrids 7a – 7l were designed, synthesized, and evaluated against Gram-positive and Gram-negative bacteria. A significant part of the title compounds showed considerable antibacterial activity against Gram-positive species. The most potent compound against Gram-positive bacteria was 2-chloro derivative 7h and the most potent derivative against Gram-negative bacteria was 3-chloro compound 7i. In vitro antibacterial evaluation of compound 7h against clinically isolated bacteria methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) showed that this compound acted better than ciprofloxacin against the latter bacteria. Docking study of compound 7h in the active site of S. aureus DNA gyrase revealed that this ciprofloxacin-dithiocarbamate derivative interacted with the main components of the active site of the enzyme. © 2018 Wiley-VHCA AG, Zurich, Switzerland

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Style	Citing Format
MLA	Esfahani EN, et al.. "Biology-Oriented Drug Synthesis (Biods) Approach Towards Synthesis of Ciprofloxacin-Dithiocarbamate Hybrids and Their Antibacterial Potential Both in Vitro and in Silico." Chemistry and Biodiversity, vol. 15, no. 10, 2018, pp. -.
APA	Esfahani EN, Mohammadikhanaposhtani M, Rezaei Z, Valizadeh Y, Rajabnia R, Bagheri M, Bandarian F, Faramarzi MA, Samadi N, Amini MR, Mahdavi M, Larijani B (2018). Biology-Oriented Drug Synthesis (Biods) Approach Towards Synthesis of Ciprofloxacin-Dithiocarbamate Hybrids and Their Antibacterial Potential Both in Vitro and in Silico. Chemistry and Biodiversity, 15(10), -.
Chicago	Esfahani EN, Mohammadikhanaposhtani M, Rezaei Z, Valizadeh Y, Rajabnia R, Bagheri M, Bandarian F, et al.. "Biology-Oriented Drug Synthesis (Biods) Approach Towards Synthesis of Ciprofloxacin-Dithiocarbamate Hybrids and Their Antibacterial Potential Both in Vitro and in Silico." Chemistry and Biodiversity 15, no. 10 (2018): -.
Harvard	Esfahani EN et al. (2018) 'Biology-Oriented Drug Synthesis (Biods) Approach Towards Synthesis of Ciprofloxacin-Dithiocarbamate Hybrids and Their Antibacterial Potential Both in Vitro and in Silico', Chemistry and Biodiversity, 15(10), pp. -.
Vancouver	Esfahani EN, Mohammadikhanaposhtani M, Rezaei Z, Valizadeh Y, Rajabnia R, Bagheri M, et al.. Biology-Oriented Drug Synthesis (Biods) Approach Towards Synthesis of Ciprofloxacin-Dithiocarbamate Hybrids and Their Antibacterial Potential Both in Vitro and in Silico. Chemistry and Biodiversity. 2018;15(10):-.
BibTex	@article{ author = {Esfahani EN and Mohammadikhanaposhtani M and Rezaei Z and Valizadeh Y and Rajabnia R and Bagheri M and Bandarian F and Faramarzi MA and Samadi N and Amini MR and Mahdavi M and Larijani B}, title = {Biology-Oriented Drug Synthesis (Biods) Approach Towards Synthesis of Ciprofloxacin-Dithiocarbamate Hybrids and Their Antibacterial Potential Both in Vitro and in Silico}, journal = {Chemistry and Biodiversity}, volume = {15}, number = {10}, pages = {-}, year = {2018} }
RIS	TY - JOUR AU - Esfahani EN AU - Mohammadikhanaposhtani M AU - Rezaei Z AU - Valizadeh Y AU - Rajabnia R AU - Bagheri M AU - Bandarian F AU - Faramarzi MA AU - Samadi N AU - Amini MR AU - Mahdavi M AU - Larijani B TI - Biology-Oriented Drug Synthesis (Biods) Approach Towards Synthesis of Ciprofloxacin-Dithiocarbamate Hybrids and Their Antibacterial Potential Both in Vitro and in Silico JO - Chemistry and Biodiversity VL - 15 IS - 10 SP - EP - PY - 2018 ER -

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