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Application of Povdone-Iodine at Delivery Significantly Increases Maternal Urinary Iodine But Not Neonatal Thyrotropin in an Area With Iodine Sufficiency Publisher Pubmed



Valizadeha M1, 2 ; Nazeria P3 ; Fazli F4 ; Mohammadian F4 ; Kalantari S4 ; Kamali K5 ; Osali H4
Authors
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Authors Affiliations
  1. 1. Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, Tehran, Iran
  2. 2. Internal Medicine and Endocrinology, Zanjan Metabolic Disease Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
  3. 3. Family Health Institute, Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Zanjan University of Medical Sciences, Zanjan, Iran
  5. 5. Department of Public Health, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran

Source: Journal of Pediatric Endocrinology and Metabolism Published:2017


Abstract

Background: The aim of the present study was to investigate the effect of povidone-iodine (PVP-I) application at delivery on maternal urinary iodine concentration (UIC) and neonatal thyrotropin concentration. Methods: In this cross-sectional study, urine samples were collected from each pregnant woman after admission to the hospital and before routine application of the PVP-I for delivery preparation and after delivery at time of screening for congenital hypothyroidism. A heel-prick blood sample was taken from all newborns. Results: A total of 394 pregnant women at time of delivery participated in this study. Median (interquartile range [IQR]) maternal UIC values were 120 (105-157) and 253 (126-470) μg/L before and after delivery, respectively (p < 0.001). No significant correlations were observed between maternal UIC before and after delivery and neonatal thyrotropin levels. Conclusions: Application of PVP-I significantly increased UIC in postpartum mothers; however, thyrotropin concentration in neonates, whose mothers had adequate UIC, was within the normal range.
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