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The Relationship Between Dietary Approaches to Stop Hypertension Diet Adherence and Inflammatory Factors and Insulin Resistance in Overweight and Obese Women: A Cross-Sectional Study Publisher Pubmed



Taheri A1 ; Mirzababaei A2 ; Setayesh L2 ; Yarizadeh H2 ; Shiraseb F2 ; Imani H3 ; Ct Clark C4 ; Mirzaei K2
Authors
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Authors Affiliations
  1. 1. Department of Nutrition, Faculty of Medicine, Sciences and Research Branch, Islamic Azad, University, Tehran, Iran
  2. 2. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  3. 3. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Iran
  4. 4. Centre for Intelligent Healthcare, Coventry University, Coventry, CV1 5FB, United Kingdom

Source: Diabetes Research and Clinical Practice Published:2021


Abstract

Background: Although there is abundant evidence for an association between dietary pattern, weight, and other related factors, such as homeostatic model assessment for insulin resistance (HOMA-IR) and inflammatory markers; there is limited information pertaining to levels of plasminogen activator inhibitor-1 (PAI-1) and Monocyte Chemoattractant Protein −1 (MCP-1). Therefore, this study sought to examine the association between adherence to the dietary approaches to stop hypertension (DASH) diet and levels of inflammatory factors PAI-1, MCP-1, and HOMA-IR. Methods: This cross-sectional study was performed on 305 obese and overweight women. The typical food intake of individuals was assessed using the 147 items semi-quantitative food frequency questionnaire (FFQ). Body components were measured for all participants. Insulin resistance was estimated by homeostasis model assessment (HOMA), and biochemical parameters were examined. Results: No significant relationship was observed between the DASH diet and MCP-1 (P-trend = 0.70), PAI-1 (P-trend = 0.92), or HOMA-IR (P-trend = 0.08) in the crude model. However, there was a significant inverse relationship between the DASH diet and HOMA-IR (P-trend = 0.03) after adjusting for age, BMI, and physical activity. Conclusion: This study showed that higher adherence to DASH pattern is inversely correlated with HOMA-IR in overweight and obese women. © 2021
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