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Adherence to the Dietary Approaches to Stop Hypertension (Dash) Diet and Risk of Total and Cause-Specific Mortality: Results From the Golestan Cohort Study Publisher Pubmed



Mokhtari Z1 ; Sharafkhah M1 ; Poustchi H2 ; Sepanlou SG3 ; Khoshnia M1, 4 ; Gharavi A1, 4 ; Sohrabpour AA2 ; Sotoudeh M1, 2, 3 ; Dawsey SM5 ; Boffetta P6 ; Abnet CC5 ; Kamangar F1, 7 ; Etemadi A1, 5 ; Pourshams A1 Show All Authors
Authors
  1. Mokhtari Z1
  2. Sharafkhah M1
  3. Poustchi H2
  4. Sepanlou SG3
  5. Khoshnia M1, 4
  6. Gharavi A1, 4
  7. Sohrabpour AA2
  8. Sotoudeh M1, 2, 3
  9. Dawsey SM5
  10. Boffetta P6
  11. Abnet CC5
  12. Kamangar F1, 7
  13. Etemadi A1, 5
  14. Pourshams A1
  15. Fazeltabarmalekshah A1
  16. Islami F1, 8
  17. Brennan P9
  18. Malekzadeh R1
  19. Hekmatdoost A10, 11
Show Affiliations
Authors Affiliations
  1. 1. Digestive Oncology Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Liver and Pancreaticobiliary Disease Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Digestive Diseases Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Golestan Research Center of Gasteroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences, Gorgan, Iran
  5. 5. Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
  6. 6. Icahn School of Medicine at Mount Sinai, New York, NY, United States
  7. 7. Department of Biology, School of Computer, Mathematical, and Natural Sciences, Morgan State University, Baltimore, MD, United States
  8. 8. Surveillance and Health Services Research, American Cancer Society, Atlanta, GA, United States
  9. 9. Genetic Epidemiology Group, International Agency for Research on Cancer (IARC/WHO), Lyon, France
  10. 10. Departments of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  11. 11. Division of Gastroenterology, Hepatology and Nutrition, UBC, BC, Canada

Source: International Journal of Epidemiology Published:2019


Abstract

Objective: To evaluate the association between adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and overall and cause-specific mortality in the Golestan Cohort Study (GCS). Methods: A total of 50 045 participants aged 40 years or older were recruited from Golestan Province, Iran, from 2004 to 2008 and followed for a mean of 10.64 years. The DASH diet score was calculated for each individual based on food groups. The primary outcome measure was death from any cause. Results: During 517 326 person-years of follow-up, 6763 deaths were reported. After adjustment for potential confounders, DASH diet score was inversely associated with risk of death from all causes and cancers [hazard ratio (HR): 0.86; 95% confidence interval (CI): 0.75, 0.98; and HR: 0.65; 95% CI: 0.47, 0.90, respectively]. A higher DASH diet score was associated with lower risk of gastrointestinal cancer mortality in men (HR: 0.55; 95% CI: 0.30, 0.99). A greater adherence to DASH diet was also associated with lower other-cancer mortality in women (HR: 0.50; 95% CI: 0.24, 0.99). No association between DASH diet score and cardiovascular disease mortality was observed, except that those dying of cardiovascular disease were younger than 50 years of age and smokers. Conclusions: Our findings suggest that maintaining a diet similar to the DASH diet is independently associated with reducing the risk of total death, cancers, and especially gastrointestinal cancers in men. © 2019 The Author(s) 2019; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.
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