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Ascorbic Acid Reduces the Blood Boss After Total Knee Arthroplasty: Insights From a Randomized Controlled Trial Publisher



Hosseinimonfared P1 ; Mirahmadi A1 ; Sarzaeem MM2 ; Pourshahryari S1 ; Aminnia P1 ; Poursalehian M3 ; Kazemi SM1
Authors
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Authors Affiliations
  1. 1. Bone Joint and Related Tissues Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Joint Reconstruction Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Arthroplasty Today Published:2025


Abstract

Background: Blood loss is among the main complications of total knee arthroplasty (TKA) and oxidative stress, and hemolysis caused by reactive oxygen species are one of the causes of hemoglobin (Hb) drop. Ascorbic acid is a potent antioxidant that can protect against reactive oxygen species. In this study, we aim to explore the antioxidant effect of ascorbic acid on blood loss and patient-reported outcomes following outpatient TKA. Methods: Patients scheduled for outpatient primary TKA were enrolled in this randomized, double-blind clinical trial and were assigned to 1 of the 2 groups. The patients in the ascorbic acid group received intravenous vitamin C perioperatively. Patients in the placebo group received only normal saline. We calculated the blood loss using the Hb drop. Patient-reported outcomes such as Oxford Knee Score, Western Ontario and McMaster Universities Osteoarthritis Index, Knee Injury and Osteoarthritis Outcome Score, and Forgotten Joint Score were used to evaluate the postoperative pain and function in the 6-month follow-up. Results: The patients who have received ascorbic acid had lower Hb drop (g/dL) (1.30 ± 0.72 vs 1.91 ± 0.84, P value <.001) and total blood loss in the first postoperative day (463.60 ± 274.37 vs 732.11 ± 347.78, P value <.001). Also, fewer patients reached the minimum clinically important difference level for Hb drop in the ascorbic acid group. The patients’ postoperative functional and pain scores were not different between the 2 groups. Conclusions: Our findings demonstrated that perioperative use of ascorbic acid can reduce blood loss by nearly 36% on the first postoperative day and should be considered as an effective blood-preserving agent in conjunction with tranexamic acid during TKA. © 2025 The Authors
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