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Development of Optical Biosensor Technologies for Cardiac Troponin Recognition Publisher Pubmed



Abdolrahim M1 ; Rabiee M1 ; Alhosseini SN1 ; Tahriri M1, 2, 3 ; Yazdanpanah S1 ; Tayebi L4, 5
Authors
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Authors Affiliations
  1. 1. Biomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
  2. 2. Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Dental Biomaterials, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Developmental Sciences, Marquette University School of Dentistry, Milwaukee, 53201, WI, United States
  5. 5. Biomaterials and Advanced Drug Delivery Laboratory, School of Medicine, Stanford University, Palo Alto, 94304, CA, United States

Source: Analytical Biochemistry Published:2015


Abstract

Acute myocardial infarction (AMI) is the leading cause of death among cardiovascular diseases. Among the numerous attempts to develop coronary marker concepts into clinical strategies, cardiac troponin is known as a specific marker for coronary events. The cardiac troponin concentration level in blood has been shown to rise rapidly for 4-10 days after onset of AMI, making it an attractive approach for a long diagnosis window for detection. The extremely low clinical sensing range of cardiac troponin levels consequently makes the methods of detection highly sensitive. In this review, by taking into consideration optical methods applied for cardiac troponin detection, we discuss the most commonly used methods of optical immunosensing and provide an overview of the various diagnostic cardiac troponin immunosensors that have been employed for determination of cardiac troponin over the last several years. © 2015 Elsevier Inc. All rights reserved.