Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Nanoscale Technologies for Prevention and Treatment of Heart Failure: Challenges and Opportunities Publisher Pubmed



Hajipour MJ1 ; Mehrani M2 ; Abbasi SH2 ; Amin A3 ; Kassaian SE2 ; Garbern JC4, 5 ; Caracciolo G6 ; Zanganeh S7 ; Chitsazan M3 ; Aghaverdi H8 ; Kamali Shahri SM8 ; Ashkarran A1, 8 ; Raoufi M9 ; Bauserheaton H15 Show All Authors
Authors
  1. Hajipour MJ1
  2. Mehrani M2
  3. Abbasi SH2
  4. Amin A3
  5. Kassaian SE2
  6. Garbern JC4, 5
  7. Caracciolo G6
  8. Zanganeh S7
  9. Chitsazan M3
  10. Aghaverdi H8
  11. Kamali Shahri SM8
  12. Ashkarran A1, 8
  13. Raoufi M9
  14. Bauserheaton H15
  15. Zhang J10
  16. Muehlschlegel JD8
  17. Moore A1
  18. Lee RT4, 11
  19. Wu JC12, 13
  20. Serpooshan V14, 15
  21. Mahmoudi M1, 8, 16
Show Affiliations
Authors Affiliations
  1. 1. Precision Health Program, Michigan State University, East Lansing, 48824, MI, United States
  2. 2. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Science, Tehran, Iran
  4. 4. Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, 02138, MA, United States
  5. 5. Department of Cardiology, Boston Children's Hospital, Boston, 02115, MA, United States
  6. 6. Department of Molecular Medicine, Sapienza University of Rome, V.le Regina Elena 291, Rome, 00161, Italy
  7. 7. Department of Radiology, Memorial Sloan Kettering, New York, 10065, NY, United States
  8. 8. Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, MA, United States
  9. 9. Physical Chemistry i, Department of Chemistry and Biology and Research Center of Micro and Nanochemistry and Engineering, University of Siegen, Siegen, 57068, Germany
  10. 10. Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, United States
  11. 11. Department of Medicine, Division of Cardiology, Brigham and Women's Hospital and Harvard Medical School, Cambridge, 02115, MA, United States
  12. 12. Stanford Cardiovascular Institute, Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, 94305, CA, United States
  13. 13. Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, 94305, CA, United States
  14. 14. Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, 30332, GA, United States
  15. 15. Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States
  16. 16. Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, MA, United States

Source: Chemical Reviews Published:2019


Abstract

The adult myocardium has a limited regenerative capacity following heart injury, and the lost cells are primarily replaced by fibrotic scar tissue. Suboptimal efficiency of current clinical therapies to resurrect the infarcted heart results in injured heart enlargement and remodeling to maintain its physiological functions. These remodeling processes ultimately leads to ischemic cardiomyopathy and heart failure (HF). Recent therapeutic approaches (e.g., regenerative and nanomedicine) have shown promise to prevent HF postmyocardial infarction in animal models. However, these preclinical, clinical, and technological advancements have yet to yield substantial enhancements in the survival rate and quality of life of patients with severe ischemic injuries. This could be attributed largely to the considerable gap in knowledge between clinicians and nanobioengineers. Development of highly effective cardiac regenerative therapies requires connecting and coordinating multiple fields, including cardiology, cellular and molecular biology, biochemistry and chemistry, and mechanical and materials sciences, among others. This review is particularly intended to bridge the knowledge gap between cardiologists and regenerative nanomedicine experts. Establishing this multidisciplinary knowledge base may help pave the way for developing novel, safer, and more effective approaches that will enable the medical community to reduce morbidity and mortality in HF patients. Copyright © 2019 American Chemical Society.
Related Docs
View other Related Docs
1. Multiscale Technologies for Treatment of Ischemic Cardiomyopathy, Nature Nanotechnology (2017)
2. Nanotoxicology: Advances and Pitfalls in Research Methodology, Nanomedicine (2015)
3. Protein Corona Variation in Nanoparticles Revisited: A Dynamic Grouping Strategy, Colloids and Surfaces B: Biointerfaces (2019)
4. Gold Nanoparticles for Biomedical Imaging and Their Biological Response, New Developments in Gold Nanomaterials Research (2016)
5. Targeted Superparamagnetic Iron Oxide Nanoparticles for Early Detection of Cancer: Possibilities and Challenges, Nanomedicine: Nanotechnology# Biology# and Medicine (2016)
6. Biomedical Applications of Superparamagnetic Nanoparticles in Molecular Scale, Current Organic Chemistry (2015)
7. Protein Corona: Opportunities and Challenges, International Journal of Biochemistry and Cell Biology (2016)
8. Superparamagnetic Iron Oxide Nanoparticles for in Vivo Molecular and Cellular Imaging, Contrast Media and Molecular Imaging (2015)
Experts (# of related papers)
View all Related Experts
Rassoul Dinarvand (18)
Fatemeh Atyabi (17)
Other Related Docs
9. Misinterpretation in Nanotoxicology: A Personal Perspective, Chemical Research in Toxicology (2016)
10. The Impact of Protein Corona on the Biological Behavior of Targeting Nanomedicines, International Journal of Pharmaceutics (2022)
11. Molecular Interaction of Fibrinogen With Zeolite Nanoparticles, Scientific Reports (2019)
12. Nanoparticles and Biological Environment Interactions, Advanced Structured Materials (2019)
13. Disease Specific Protein Corona, Progress in Biomedical Optics and Imaging - Proceedings of SPIE (2015)
14. Engineering the Nanoparticle-Protein Interface for Cancer Therapeutics, Cancer Treatment and Research (2015)
15. Protein Corona: Challenges and Opportunities for Cancer Therapy, Functionalized Nanomaterials for Cancer Research: Applications in Treatments# Tools and Devices (2024)
16. Current Status of Stem Cell Therapy and Nanofibrous Scaffolds in Cardiovascular Tissue Engineering, Regenerative Engineering and Translational Medicine (2022)
17. Synthetic and Biological Identities of Polymeric Nanoparticles Influencing the Cellular Delivery: An Immunological Link, Journal of Colloid and Interface Science (2019)
18. Biological Identity of Nanoparticles in Vivo: Clinical Implications of the Protein Corona, Trends in Biotechnology (2017)
19. Immunoengineering in Glioblastoma Imaging and Therapy, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology (2019)
20. Crucial Role of the Protein Corona for the Specific Targeting of Nanoparticles, Nanomedicine (2015)
21. Impact of Plasma Concentration of Transferrin on Targeting Capacity of Nanoparticles, Nanoscale (2020)
22. Biomolecular Corona Dictates Aβ Fibrillation Process, ACS Chemical Neuroscience (2018)
23. Targeting Non-Apoptotic Cell Death in Cancer Treatment by Nanomaterials: Recent Advances and Future Outlook, Nanomedicine: Nanotechnology# Biology# and Medicine (2020)
24. Advances in Alzheimer's Diagnosis and Therapy: The Implications of Nanotechnology, Trends in Biotechnology (2017)
25. Novel Therapeutic Strategies for Alzheimer's Disease: Implications From Cell-Based Therapy and Nanotherapy, Nanomedicine: Nanotechnology# Biology# and Medicine (2020)
26. Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles in Different Tissues, Artificial Cells# Nanomedicine and Biotechnology (2020)
27. Regulation of Cell Fate by Cell Imprinting Approach in Vitro, BioImpacts (2024)
28. Ischemic Cardiomyopathy, Nanomedicine for Ischemic Cardiomyopathy: Progress# Opportunities# and Challenges (2020)
29. Novel Mri Contrast Agent From Magnetotactic Bacteria Enables in Vivo Tracking of Ipsc-Derived Cardiomyocytes, Scientific Reports (2016)
30. Myocardial Cell Signaling During the Transition to Heart Failure: Cellular Signaling and Therapeutic Approaches, Comprehensive Physiology (2019)
31. Dual Nano-Sized Contrast Agents in Pet/Mri: A Systematic Review, Contrast Media and Molecular Imaging (2016)
32. The Therapeutic Potential of Nanoparticles to Reduce Inflammation in Atherosclerosis, Biomolecules (2019)
33. Development of a Virtual Cell Model to Predict Cell Response to Substrate Topography, ACS Nano (2017)
34. Monoclonal Antibody Conjugated Magnetic Nanoparticles Could Target Muc-1-Positive Cells in Vitro But Not in Vivo, Contrast Media and Molecular Imaging (2015)
35. The Importance of Selecting a Proper Biological Milieu for Protein Corona Analysis in Vitro: Human Plasma Versus Human Serum, International Journal of Biochemistry and Cell Biology (2016)
36. Zeolite Nanoparticles Inhibit Aβ-Fibrinogen Interaction and Formation of a Consequent Abnormal Structural Clot, ACS Applied Materials and Interfaces (2016)
37. Pharmacologic Prevention of Myocardial Ischemia-Reperfusion Injury in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention, Journal of Cardiovascular Pharmacology (2021)
38. Photothermal Effects on Protein Adsorption Dynamics of Pegylated Gold Nanorods, Applied Materials Today (2019)
39. Future Perspective on the Smart Delivery of Biomolecules, Drug Delivery Systems (2017)
40. Regulation of Macrophage Recognition Through the Interplay of Nanoparticle Surface Functionality and Protein Corona, ACS Nano (2016)
41. Identification of Nanoparticles With a Colorimetric Sensor Array, ACS Sensors (2016)
42. Nanomedicine and Advanced Technologies for Burns: Preventing Infection and Facilitating Wound Healing, Advanced Drug Delivery Reviews (2018)
43. Restoring Endogenous Repair Mechanisms to Heal Chronic Wounds With a Multifunctional Wound Dressing, Molecular Pharmaceutics (2021)
44. Regulation of Stem Cell Fate by Nanomaterial Substrates, Nanomedicine (2015)
45. Sensing of Alzheimer's Disease and Multiple Sclerosis Using Nano-Bio Interfaces, Journal of Alzheimer's Disease (2017)
46. The Bio-Interface Between Functionalized Au Nr@Go Nanoplatforms With Protein Corona and Their Impact on Delivery and Release System, Colloids and Surfaces B: Biointerfaces (2019)
47. Molecular Imprinting As a Simple Way for the Long-Term Maintenance of the Stemness and Proliferation Potential of Adipose-Derived Stem Cells: An in Vitro Study, Journal of Materials Chemistry B (2022)
48. Stem Cell Therapy: A New Therapeutic Option for Cardiovascular Diseases, Journal of Cellular Biochemistry (2018)
49. Tenocyte-Imprinted Substrate: A Topography-Based Inducer for Tenogenic Differentiation in Adipose Tissue-Derived Mesenchymal Stem Cells, Biomedical Materials (Bristol) (2020)
50. Development of Optical Biosensor Technologies for Cardiac Troponin Recognition, Analytical Biochemistry (2015)