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Potential Role of Immunoglobulin Replacement Therapy on Mri Measures in Multiple Sclerosis: A Systematic Review Publisher Pubmed



Zareshahabadi A1, 2, 3 ; Rashidian A4, 5 ; Sahraian MA2 ; Rezaei N1, 6, 7
Authors
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Authors Affiliations
  1. 1. Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Knowledge Utilization Research Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Universal Scientific Education and Research Network (USERN), Tehran, Iran
  7. 7. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Childrens Medical Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Expert Review of Clinical Immunology Published:2015


Abstract

Multiple sclerosis is a chronic immune-mediated disease of the nervous system. In the early disease course, axonal loss and neurodegeneration occurs that could possibly lead to irreversible neurological impairments. Preventing brain atrophy may have important clinical implications affecting treatment decisions in the future. In recent years, research efforts have directed towards finding agents to modify the disease and reduce brain volume loss. Intravenous immunoglobulin (IVIg) may have some potential roles in this regard. © 2015 © 2015 Taylor & Francis.
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