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Immune-Mediated Cognition Impairment in Multiple Sclerosis Publisher



Kolahchi Z1, 2 ; Saien S1 ; Khaboushan AS1, 3 ; Naghavi E1 ; Perry G4 ; Rezaei N2, 5, 6
Authors
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Authors Affiliations
  1. 1. Students’ International Committee of Medical Schools (SICoMS), School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. The University of Texas at San Antonio, San Antonio, TX, United States
  5. 5. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Immunology, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: Translational Neuroimmunology: Multiple Sclerosis: Volume 8 Published:2023


Abstract

Multiple sclerosis (MS) is a chronic disorder associated with inflammation and degeneration of neurons in the central nervous system (CNS). Cognitive impairment is one of the most common MS symptoms that can be recognized in 40%–70% of MS patients. In this chapter, we have summarized the literature about the role of immune factors in cognitive impairment. Cognitive impairment in MS patients is influenced by immune cells and cytokines, such as IL-6, IL-8, IL-10, IL-17, IL-18, and TNF-α, which may reveal the underlying mechanisms that are therapeutically addressable. © 2023 Elsevier Inc. All rights reserved.
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