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Higher Serum Level of Ctrp15 in Patients With Coronary Artery Disease Is Associated With Disease Severity, Body Mass Index and Insulin Resistance Publisher Pubmed



Shokoohi Nahrkhalaji A1 ; Ahmadi R2 ; Fadaei R3 ; Panahi G4 ; Razzaghi M1 ; Fallah S1
Authors
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Authors Affiliations
  1. 1. Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
  3. 3. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Archives of Physiology and Biochemistry Published:2022


Abstract

Background: CTRP15 is a prologue of adiponectin which has shown to have favourable effects on glucose and lipid metabolism. Studies have reported lower levels of CTRP15 in T2DM and metabolic syndrome; however, its circulating levels have not been evaluated in CAD patients. Methods: This case–control study was conducted on 190 angiographically confirmed coronary artery disease (CAD) patients and 70 controls. Serum levels of CTRP15, adiponectin, TNF-α, and IL-6 were measured using the ELISA technique. Results: CTRP15 was shown to occur in higher levels in CAD patients compared with controls. In CAD patients, CTRP15 showed a positive correlation with BMI, FBS, insulin, HOMA-IR, IL-6, and TNF-α and a negative correlation with HDL-C and adiponectin. Conclusion: Elevated levels of CTRP15 in CAD patients and the relation of CTRP15 with pathogenic conditions such as insulin resistance, inflammation, and decreased adiponectin and HDL-C suggest a possible compensatory response to these conditions in CAD patients. © 2019 Informa UK Limited, trading as Taylor & Francis Group.
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