Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Decreased Serum Levels of Ctrp12/Adipolin in Patients With Coronary Artery Disease in Relation to Inflammatory Cytokines and Insulin Resistance Publisher Pubmed



Fadaei R1, 2 ; Moradi N3, 4 ; Kazemi T5 ; Chamani E6 ; Azdaki N5 ; Moezibady SA5 ; Shahmohamadnejad S2 ; Fallah S3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Clinical Biochemistry, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
  5. 5. Cardiovascular Diseases Research Centre, Department of Cardiology, Birjand University of Medical Sciences, Birjand, Iran
  6. 6. Cardiovascular Diseases Research Centre, Department of Biochemistry, Birjand University of Medical Sciences, Birjand, Iran

Source: Cytokine Published:2019


Abstract

Coronary artery disease (CAD) is the leading cause of death worldwide. Atherosclerosis as the main underlying mechanism of CAD is associated with inflammation and adipose tissue dysfunction. C1q/TNF-related protein12 (CTRP12) is a newly discovered adipokine which is a paralog of adiponectin. CTRP12 has anti-inflammatory and insulin sensitizing effects. Circulating levels of this adipokine have been reported to be lower in patients with type 2 diabetes and women with polycystic ovarian syndrome. The present study was undertaken for the first time to evaluate serum levels of CTRP12 in CAD patients and its association with anthropometric and biochemical parameters. Serum levels of CTRP12 were measured using ELISA kit in 188 CAD patients (angiography confirmed) and 70 controls. The serum levels of adiponectin, TNF-α and IL-6 were measured using ELISA kits. Serum levels of CTRP12 were found to be lower in CAD patients (585.48 ± 201.67 pg/mL) than in the controls (814.86 ± 247.85 pg/mL; p < 0.001). CTRP12 also showed an independent association with the risk of CAD (OR [CI] = 0.998 [0.996–0.999]; p = 0.019). Moreover, it showed an inverse correlation with HOMA-IR (r = −0.298; p = 0.012) and TNF-α (r = −0.269; p = 0.023) and a positive correlation with adiponectin (r = 0.344; p = 0.003) in the controls. In CAD patients, CTRP12 was inversely correlated with BMI (r = −0.181, p = 0.013), HOMA-IR (r = -0.199; p = 0.006), TNF-α (r = -0.259; p < 0.001) and IL-6 (r = -320; p < 0.001) and a positive correlation with high density lipoprotein-cholesterol(r = 0.342; p < 0.001) and adiponectin (r = 0.398; p < 0.001). The present study showed for the first time that serum levels of CTRP12 are independently associated with CAD and that CTRP12 is associated with several CAD risk factors. The results suggest a possible link between CTRP12 and pathogenic mechanisms of atherosclerosis, such as inflammation and high density lipoprotein-cholesterol metabolism; however, more study is required in this regard. © 2018 Elsevier Ltd
Related Docs
View other Related Docs
1. The C1q/Tnf-Related Proteins (Ctrps) in Pathogenesis of Obesity-Related Metabolic Disorders: Focus on Type 2 Diabetes and Cardiovascular Diseases, Life Sciences (2020)
2. The Gene Expression of Ctrp12 But Not Ctrp13 Is Upregulated in Both Visceral and Subcutaneous Adipose Tissue of Obese Subjects, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2019)
3. Association of C1q/Tnf-Related Protein-3 (Ctrp3) and Ctrp13 Serum Levels With Coronary Artery Disease in Subjects With and Without Type 2 Diabetes Mellitus, PLoS ONE (2016)
4. Lower Circulating Levels of Ctrp12 and Ctrp13 in Polycystic Ovarian Syndrome: Irrespective of Obesity, PLoS ONE (2018)
5. Lower Serum Levels of Meteorin-Like/Subfatin in Patients With Coronary Artery Disease and Type 2 Diabetes Mellitus Are Negatively Associated With Insulin Resistance and Inflammatory Cytokines, PLoS ONE (2018)
6. Ctrp1 in Liver Disease, Advances in Clinical Chemistry (2017)
7. The Circulating Levels of Ctrp1 and Ctrp5 Are Associated With Obesity Indices and Carotid Intima-Media Thickness (Cimt) Value in Patients With Type 2 Diabetes: A Preliminary Study, Diabetology and Metabolic Syndrome (2021)
8. Association of Circulating Ctrp9 With Soluble Adhesion Molecules and Inflammatory Markers in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease, PLoS ONE (2018)
Experts (# of related papers)
View all Related Experts
Solaleh Emamgholipour (9)
Hossein Poustchi (6)
Other Related Docs
9. Circulating Levels of C1q/Tnf-Α‐Related Protein 6 (Ctrp6) in Coronary Artery Disease and Its Correlation With Inflammatory Markers, Journal of Diabetes and Metabolic Disorders (2024)
10. Serum C1q/Tnf-Related Protein-2 (Ctrp2) Levels Are Associated With Coronary Artery Disease, Archives of Medical Research (2020)
11. The Circulating Ctrp13 in Type 2 Diabetes and Non-Alcoholic Fatty Liver Patients, PLoS ONE (2016)
12. The Circulating Levels of Complement-Clq/Tnf-Related Protein 13 (Ctrp13) in Patients With Type 2 Diabetes and Its Association With Insulin Resistance, Clinical Laboratory (2017)
13. Evaluation of Changing the Pattern of Ctrp5 and Inflammatory Markers Levels in Patients With Coronary Artery Disease and Type 2 Diabetes Mellitus, Archives of Physiology and Biochemistry (2022)
14. Higher Serum Level of Ctrp15 in Patients With Coronary Artery Disease Is Associated With Disease Severity, Body Mass Index and Insulin Resistance, Archives of Physiology and Biochemistry (2022)
15. Circulating Levels of C1q/Tnf-Α-Related Protein 6 (Ctrp6) in Polycystic Ovary Syndrome, IUBMB Life (2020)
16. Circulating Ctrp5 in Rheumatoid Arthritis: An Exploratory Biomarker Study, BMC Rheumatology (2022)
17. Role of Type 2 Diabetes and Hemodialysis in Serum Adipolin Concentrations: A Preliminary Study, Hemodialysis International (2019)
18. The Effect of Coenzyme Q10 Supplementation on Circulating Levels of Novel Adipokine Adipolin/Ctrp12 in Overweight and Obese Patients With Type 2 Diabetes, Experimental and Clinical Endocrinology and Diabetes (2017)
19. The Effects of 12 Weeks of Concurrent and Combined Training on Inflammatory Markers, Muscular Performance, and Body Composition in Middle-Aged Overweight and Obese Males, Nutrients (2023)
20. The Relationship Between Serum Adipokines and Glucose Homeostasis in Normal-Weight and Obese Patients on Hemodialysis: A Preliminary Study, International Urology and Nephrology (2020)
21. Increased Mrna Expression of Ctrp3 and Ctrp9 in Adipose Tissue From Obese Women: Is It Linked to Obesity-Related Parameters and Mrna Expression of Inflammatory Cytokines?, Reports of Biochemistry and Molecular Biology (2020)
22. The Impacts of C1q/Tnf-Related Protein-15 and Adiponectin on Interleukin-6 and Tumor Necrosis Factor-Α in Primary Macrophages of Patients With Coronary Artery Diseases, Cytokine (2021)
23. Mir-342-5P Expression Levels in Coronary Artery Disease Patients and Its Association With Inflammatory Cytokines, Clinical Laboratory (2018)
24. Serum Levels of Subfatin in Patients With Type 2 Diabetes Mellitus and Its Association With Vascular Adhesion Molecules, Archives of Physiology and Biochemistry (2020)
25. Association of Carotid Intima Media Thickness With Atherogenic Index of Plasma, Apo B/Apo A-I Ratio and Paraoxonase Activity in Patients With Non-Alcoholic Fatty Liver Disease, Archives of Physiology and Biochemistry (2019)
26. Plasma Complement C1q/Tumor Necrosis Factor-Related Protein 15 Concentration Is Associated With Polycystic Ovary Syndrome, PLoS ONE (2022)
27. Interleukin 17, the Double-Edged Sword in Atherosclerosis, Immunobiology (2022)
28. Role of Serum Mmp-9 Levels and Vitamin D Receptor Polymorphisms in the Susceptibility to Coronary Artery Disease: An Association Study in Iranian Population, Gene (2017)
29. Circulating Levels of Fam19a5 Are Inversely Associated With Subclinical Atherosclerosis in Non-Alcoholic Fatty Liver Disease, BMC Endocrine Disorders (2021)
30. Circulating Level of Ctrp1 in Patients With Nonalcoholic Fatty Liver Disease (Nafld): Is It Through Insulin Resistance?, PLoS ONE (2015)
31. Lkb1: An Emerging Therapeutic Target for Cardiovascular Diseases, Life Sciences (2022)
32. Construction of an Exudative Age-Related Macular Degeneration Diagnostic and Therapeutic Molecular Network Using Multi-Layer Network Analysis, a Fuzzy Logic Model, and Deep Learning Techniques: Are Retinal and Brain Neurodegenerative Disorders Related?, Pharmaceuticals (2023)
33. Serum Levels of Asprosin in Patients Diagnosed With Coronary Artery Disease (Cad): A Case-Control Study, Lipids in Health and Disease (2021)
34. Increased Circulating Level of Ctrp15 in Patients With Type 2 Diabetes Mellitus and Its Relation With Inflammation and Insulin Resistance, Journal of Diabetes and Metabolic Disorders (2021)
35. Serum Levels of C1q/Tnf-Related Protein-3 in Inflammatory Bowel Disease Patients and Its Inverse Association With Inflammatory Cytokines and Insulin Resistance, IUBMB Life (2020)
36. The Association of Circulating Levels of Complement-C1q Tnf-Related Protein 5 (Ctrp5) With Nonalcoholic Fatty Liver Disease and Type 2 Diabetes: A Case-Control Study, Diabetology and Metabolic Syndrome (2015)
37. C1q/Tnf-Related Protein-1: Potential Biomarker for Early Diagnosis of Autism Spectrum Disorder, International Journal of Immunopathology and Pharmacology (2022)