Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Human Cytomegalovirus Infection in Iranian Glioma Patients Correlates With Aging and Tumor Aggressiveness Publisher Pubmed



Maleki F1 ; Sadigh ZA1 ; Sadeghi F2 ; Muhammadnejad A3 ; Farahmand M4 ; Parvin M5 ; Shirkoohi R3, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Human Viral Vaccine Department, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Alborz Province, Iran
  2. 2. Department of Microbiology, Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
  3. 3. Department of Molecular Genetics, Cancer Biology Research Center, Cancer Institute of Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Tehran Province, Iran
  5. 5. Department of Pathology, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Tehran Province, Iran
  6. 6. Department of Molecular Genetics, Cancer Research Center, Cancer Institute of Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Medical Virology Published:2020


Abstract

Human cytomegalovirus (HCMV), as a ubiquitous and opportunistic virus, is a matter for consideration in broad-spectrum diseases, specifically in immunocompromised individuals. In recent decades, many studies that have evaluated the role of HCMV in inflammation and malignancies, especially in high-grade gliomas, have reported inconsistent results. Thus, this study was conducted to analyze 97 primary gliomas for human CMV UL83 gene and protein through TaqMan real-time polymerase chain reaction and immunohistochemistry, respectively. The results were positive for the UL83 gene and pp65 protein in 71% and 24% of samples, respectively. The frequency of HCMV was significantly higher in glioblastomas than other glioma grades (P <.01 and P <.05 for the UL83 gene and protein, respectively). In addition, the association between the prevalence of HCMV and aging strengthened the virus reactivation hypothesis in gliomas. In conclusion, a high frequency of HCMV infection was found in gliomas that correlated with tumor aggressiveness and age. This study recommends a thorough investigation to determine HCMV infection in gliomas to improve the existing knowledge of its role in glial tumors, its prognostic value, and possible efficient antiviral target therapy. © 2020 Wiley Periodicals, Inc.
Related Docs
1. Survey of Bk and Jc Polyomaviruses, Human Cytomegalovirus and Human Papillomavirus in Different Types of Brain Tumors in Iranian Patients, Gene Reports (2021)
2. Molecular Investigation of Human Cytomegalovirus and Epstein-Barr Virus in Glioblastoma Brain Tumor: A Case-Control Study in Iran, Iranian Biomedical Journal (2021)
3. Clinical Effects of Immuno-Oncology Therapy on Glioblastoma Patients: A Systematic Review, Brain Sciences (2023)
4. Cytomegalovirus Dna in Non-Glioblastoma Multiforme Brain Tumors of Infants, Child's Nervous System (2021)
5. Evaluation of Cellular Mir-122 Expression in Association With the Presence of Varicella-Zoster Virus Among Central Nervous System Tumors, International Journal of Cancer Management (2022)
6. Human Cytomegalovirus Infection Enhances 5‑Lipoxygenase and Cycloxygenase‑2 Expression in Colorectal Cancer, International Journal of Oncology (2023)
Experts (# of related papers)
View all Related Experts
Mohammad Vasei (1)
Nazanin Zahra Shafiei Jandaghi (1)