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Scotopic Contrast Sensitivity and Glare After Accelerated Corneal Cross-Linking Publisher Pubmed



Asgari S1, 2 ; Hashemi H2 ; Mohamadi A3 ; Jafarzadehpur E4 ; Miraftab M2 ; Shahhoseini S2 ; Mehravaran S5 ; Fotouhi A1
Authors
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Authors Affiliations
  1. 1. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran
  3. 3. Department of Optometry, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran
  5. 5. Stein Eye Institute, University of California, Los Angeles, CA, United States

Source: Clinical and Experimental Optometry Published:2018


Abstract

Background: The aim was to assess one-year changes in uncorrected and corrected contrast sensitivity (CS) and glare under scotopic conditions after accelerated cross-linking (CXL) using the 18 mW/cm2 protocol for the treatment of progressive keratoconus and compare results with unoperated controls. Methods: In this non-randomised clinical trial, 30 eyes were enrolled in the CXL group and 30 were assigned to the control group. Scotopic CS at spatial frequencies (SFs) of 0.5, 1.1, 2.2, 3.4, 7.1 and 15 cycles per degree (cpd) were assessed using the MonCv3System (Metrovision, Perenchies, France) under scotopic conditions (0.5 lux) at baseline and at six and 12 months. Results: The mean ages of the participants in the CXL and control groups were 24.32 ± 5.17 and 30.93 ± 7.43 years, respectively (p < 0.001). After adjusting for age, changes in uncorrected and corrected CS and glare were similar in the two groups (all p > 0.05) except for corrected CS at SF 7.1 cpd (1.45 ± 4.31 versus 3.21 ± 4.69 dB, p = 0.010) and 15 cpd (1.12 ± 4.63 versus 3.03 ± 5.48 dB, p = 0.007), which were reduced as an effect of CXL. Based on covariate analyses, among corrected CS indices, corrected CS7.1 and CS15 were related to CXL and their baseline values (all p < 0.050). Uncorrected CS in all SFs and uncorrected and corrected glare were related to their pre-operative values (all p < 0.001). Conclusion: Accelerated CXL can reduce scotopic corrected CS at SFs higher than 7.0 cpd in cases with better baseline values of these parameters. Changes in uncorrected CS and glare are only a factor of baseline values and the indices reduce in cases with better baseline values after one year. © 2017 Optometry Australia
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