Adherence to Oxidative Balance Scores Is Associated With a Reduced Risk of Breast Cancer; a Case-Control Study Publisher Pubmed



Sohouli MH^{1, 2} ; Baniasadi M² ; Hernandezruiz A³ ; Melekoglu E⁴ ; Zendehdel M⁵ ; Jose Sotomendez M³ ; Akbari A² ; Zarrati M⁶ Show Affiliations
Source: Nutrition and Cancer Published:2022

Abstract

We aimed to examine whether anthropometric indices, dietary factors, and nutrient intakes of women with and without breast cancer (BrCa) are associated with the oxidative balance score (OBS). This case-control study was carried out among 253 patients with BrCa and 267 healthy subjects aged >18 years. The OBS was calculated by using the following 13 dietary and non-dietary anti- and prooxidant components: dietary antioxidants (selenium, fiber, β-carotene, vitamin D, vitamin C, vitamin E, and folate), dietary prooxidants (iron and saturated and polyunsaturated fatty acids), and nondietary anti- (physical activity) and prooxidants (smoking and obesity). The binary logistic regression was used to determine the association OBS with BrCa. After adjusting for potential confounders in the final model, there was evidence that the odds of BrCa decreased with increasing categories of the OBS (OR = 0.53, 95% CI 0.28 − 0.98; P-trend = 0.021). When we made stratified analysis by menopausal status, OBS was inversely associated with odds of BrCa in premenopausal women after adjusting for potential confounders. No significant association was found between OBS and odds of BrCa among post-menopausal women. Our data suggest that OBS scores were associated with decreased BrCa risk in the overall population. © 2022 Taylor & Francis Group, LLC.