Dietary Total Antioxidant Capacity and Head and Neck Cancer: A Large Case-Control Study in Iran

Dietary Total Antioxidant Capacity and Head and Neck Cancer: A Large Case-Control Study in Iran Publisher

Toorang F^{1, 2} ; Seyyedsalehi MS^{1, 2} ; Sasanfar B^{1, 3, 4} ; Rashidian H¹ ; Hadji M^{1, 5} ; Mohebbi E⁶ ; Safari R⁷ ; Najefi F^{7, 8} ; Naghibzadehtahami A^{9, 10} ; Bofetta P^{2, 11, 12} ; Zendehdel K^{1, 2, 13}

Show Affiliations

1. Cancer Research Center, Cancer Institute, Tehran University of Medical Science, Tehran, Iran
2. Departments of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
3. Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4. Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5. Health Sciences Unit, Faculty of Social Sciences, Tampere University, Tampere, Finland
6. Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, United States
7. Research Center for Environmental Determinants of Health, School of Public Health, Kermanshah Medical Sciences University, Kermanshah, Iran
8. Social Development and Health Promotion Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
9. Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
10. Health Foresight and Innovation Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
11. Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, United States
12. Department of Family, Population and Preventive Medicine, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, United States
13. Cancer Biology Research Center, Cancer Institute, Tehran University of Medical Science, Tehran, Iran

Source: Frontiers in Nutrition Published:2023

Abstract

Background: Data on the association between head and neck cancer (HNC) and dietary factors are inconclusive. No study has so far investigated the association between dietary total antioxidant capacity (dTAC) and HNC concerning interactions with other risk factors. Method: Pathologically confirmed new diagnosed HNC patients were included in this study. The control group was healthy hospital visitors who were frequently matched with patients on age (5 years interval), gender, and province of residence. Trained interviewers administered a validated Food Frequency Questionnaire (FFQ) to assess the participants’ food intake 1 year before the cancer diagnosis. Data on TAC scores of foods was collected by Ferric Reducing Antioxidant Power (FRAP) and Total Radical-trapping Antioxidant Parameters (TRAP) from published data. We applied logistic regression adjusted for age, sex, energy intake, socioeconomic status, province, opium use, alcohol use, physical activity, and dental health. We also studied the interaction of dTAC with tobacco smoking status, and opium use on the risk of HNC. Results: We recruited 876 HNC patients and 3,409 healthy controls. We observed a significant decrease in the odds of HNC with increasing dTAC scores. The OR of HNC for the third vs. the first tertile was 0.49 (95%CI 0.39–0.61) for FRAP and 0.49 (95%CI 0.39–0.62) for TRAP. Both dTAC scores were inversely associated with lip and oral (T3 ver. T1 OR = 0.51; 95%CI 0.36–0.71 for FRAP and OR = 0.59; 95% CI 0.44–0.82 for TRAP) and larynx (T3 ver. T1 OR = 0.43; 95%CI 0.31–0.61 for FRAP and OR = 0.38; 95% CI 0.26–0.55 for TRAP) cancers. There was no interaction between tobacco smoking, opium use; and TRAP or FRAP on the risk of HNC. Conclusion: An antioxidant-rich diet in terms of FRAP or TRAP could decrease the risk of HNC and its subtypes. Copyright © 2023 Toorang, Seyyedsalehi, Sasanfar, Rashidian, Hadji, Mohebbi, Safari, Najefi, Naghibzadeh-Tahami, Bofetta and Zendehdel.

Related Docs

View other Related Docs

1. Dietary Total Antioxidant Capacity and Odds of Lung Cancer: A Large Case-Control Study, BMC Cancer (2024)

2. Dietary Inflammatory Index and Head and Neck Cancer: A Multicenter Case-Control Study in Iran, Journal of Research in Health Sciences (2024)

3. Dietary Choline and Betaine Intake and Risk of Colorectal Cancer in an Iranian Population, Cancers (2023)

4. Dietary Ruminant and Industrial Trans-Fatty Acids Intake and Colorectal Cancer Risk, Nutrients (2022)

5. Dietary Total Antioxidant Capacity and Gestational Diabetes Mellitus: A Case-Control Study, Oxidative Medicine and Cellular Longevity (2020)

6. Role of Dietary Intake of Specific Polyunsaturated Fatty Acids (Pufas) on Colorectal Cancer Risk in Iran, Lipids (2024)

7. Association Between Dietary Fat Intake and Colorectal Cancer: A Multicenter Case-Control Study in Iran, Frontiers in Nutrition (2022)

8. Association of Dietary Total Antioxidant Capacity to Anthropometry in Healthy Women: A Cross-Sectional Study, Nutrition (2020)

Experts (# of related papers)

View all Related Experts

Kazem Zendehdel (23)

Hamideh Rashidian (19)

Style	Citing Format
MLA	Toorang F, et al.. "Dietary Total Antioxidant Capacity and Head and Neck Cancer: A Large Case-Control Study in Iran." Frontiers in Nutrition, vol. 10, no. , 2023, pp. -.
APA	Toorang F, Seyyedsalehi MS, Sasanfar B, Rashidian H, Hadji M, Mohebbi E, Safari R, Najefi F, Naghibzadehtahami A, Bofetta P, Zendehdel K (2023). Dietary Total Antioxidant Capacity and Head and Neck Cancer: A Large Case-Control Study in Iran. Frontiers in Nutrition, 10(), -.
Chicago	Toorang F, Seyyedsalehi MS, Sasanfar B, Rashidian H, Hadji M, Mohebbi E, Safari R, et al.. "Dietary Total Antioxidant Capacity and Head and Neck Cancer: A Large Case-Control Study in Iran." Frontiers in Nutrition 10, no. (2023): -.
Harvard	Toorang F et al. (2023) 'Dietary Total Antioxidant Capacity and Head and Neck Cancer: A Large Case-Control Study in Iran', Frontiers in Nutrition, 10(), pp. -.
Vancouver	Toorang F, Seyyedsalehi MS, Sasanfar B, Rashidian H, Hadji M, Mohebbi E, et al.. Dietary Total Antioxidant Capacity and Head and Neck Cancer: A Large Case-Control Study in Iran. Frontiers in Nutrition. 2023;10():-.
BibTex	@article{ author = {Toorang F and Seyyedsalehi MS and Sasanfar B and Rashidian H and Hadji M and Mohebbi E and Safari R and Najefi F and Naghibzadehtahami A and Bofetta P and Zendehdel K}, title = {Dietary Total Antioxidant Capacity and Head and Neck Cancer: A Large Case-Control Study in Iran}, journal = {Frontiers in Nutrition}, volume = {10}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Toorang F AU - Seyyedsalehi MS AU - Sasanfar B AU - Rashidian H AU - Hadji M AU - Mohebbi E AU - Safari R AU - Najefi F AU - Naghibzadehtahami A AU - Bofetta P AU - Zendehdel K TI - Dietary Total Antioxidant Capacity and Head and Neck Cancer: A Large Case-Control Study in Iran JO - Frontiers in Nutrition VL - 10 IS - SP - EP - PY - 2023 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract