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Clinical Validation on Role of Cancer Diagnostic Probe in Detecting the Involved Cavity Margins Missed in Permanent Pathology of Tumor Side in Breast Cancer Surgery Publisher Pubmed



Abbasvandi F1, 2, 3 ; Miripour ZS1 ; Bayat M1, 3 ; Mousavikiasary SMS1 ; Shayanfar S3 ; Shojaeian F1, 3 ; Aghaei F1 ; Jahanbakhshi F1 ; Abbasvandi N1, 2 ; Omranihashemi M3 ; Akbari A3 ; Yousefi M3 ; Hadizadeh M1 ; Farahani NS3 Show All Authors
Authors
  1. Abbasvandi F1, 2, 3
  2. Miripour ZS1
  3. Bayat M1, 3
  4. Mousavikiasary SMS1
  5. Shayanfar S3
  6. Shojaeian F1, 3
  7. Aghaei F1
  8. Jahanbakhshi F1
  9. Abbasvandi N1, 2
  10. Omranihashemi M3
  11. Akbari A3
  12. Yousefi M3
  13. Hadizadeh M1
  14. Farahani NS3
  15. Hosseinpoor P1, 2, 4
  16. Parniani M2
  17. Nourinjad Z2
  18. Abdolahad M1, 5
  19. Akbari ME3
Show Affiliations
Authors Affiliations
  1. 1. Nano Bioelectronics Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, 4563-11155, Tehran, Iran
  2. 2. ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, 1517964311, Tehran, Iran
  3. 3. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. SEPAS Pathology Laboratory, Tehran, Iran
  5. 5. Cancer Institute, Imam-Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Diagnostic Pathology Published:2024


Abstract

Cancer diagnostic probe (CDP) as a newly entered tool in real-time breast cavity margin evaluation showed great improvement in smart margin shaving intra-operatively. This system increased the rate of involved margin detection to 30% with respect to frozen section. In this study for the first time we showed the independent role of CDP in finding the involved cavity side margins which were not diagnosed by permananet pathology of their tumor side interface. Among 147 detected margins by CDP, 23 lesions with invasive component and ductal carcinoma in-situ/ductal cancerization weren’t reported as involved margins in permanent pathology of tumor side. Our gold standard was the histology of cavity margin specimen had been scored as involved lesion by CDP. It seems that even when the permanent pathology of surgical margins is used for final declaration, role of CDP is irreplaceable. This distinguished achievement has been obtained intra-operatively in real-time by CDP while involved report in permanent pathology of tumor margins induce re-surgery for the patient. © The Author(s) 2024.
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