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Accuracy of Cancer Diagnostic Probe for Intra-Surgical Checking of Cavity Side Margins in Neoadjuvant Breast Cancer Cases: A Human Model Study Publisher Pubmed



Dabbagh N1, 2 ; Abbasvandi F1, 3, 4 ; Miripour ZS1 ; Hoseinpour P1, 4 ; Jahanbakhshi F3 ; Moradi A5 ; Riazi H2 ; Moradian F2 ; Zanjani FS6 ; Parniani M4, 7 ; Akbari ME2 ; Abdolahad M1, 8, 9
Authors
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Authors Affiliations
  1. 1. Nano Bio Electronic Devices Lab, Cancer Electronics Research Group, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran
  2. 2. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  4. 4. SEPAS Pathology Laboratory, Tehran, Iran
  5. 5. Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Pathology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  8. 8. School of Medicine, Cancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. UT-TUMS Cancer Electronics Research Center, Tehran, Iran

Source: International Journal of Medical Robotics and Computer Assisted Surgery Published:2022


Abstract

Background: Background Recently, a real-time system, named cancer diagnostic probe (CDP), has been developed to diagnose the presence of pre-neoplastic/neoplastic cells in breast cavity side margins. Detecting mechanism is real-time determination of the ROS/H2O2 released from cancer or atypical cells, through reverse Warburg effect and hypoxia glycolysis pathways. Aims: Here, we designed a human model study based on real-time checking of 387 internal margins (IM) from 39 neoadjuvant breast cancer cases by CDP. Materials & Methods: Each lesion was checked by entered needle sensor and electrical scores were recorded. The permanent pathology result of each tested lesion was our gold standard to evaluate CDP scoring. CDP results were compared with permanent pathology of tumour side margins (as a conventional margin evaluation procedure). Results: Results showed that the sensitivity of CDP in scoring the cavity side margins of those cases is 91%. A total of 18 involved IM which had been detected by CDP were declared as free margins in pathology section of tumour side samples. Just five involved IM were missed by CDP. Discussions: Such sensitivity revealed that metabolism based (here: hypoxia glycolysis) tracing of cancer cells show distinct electrochemical responses between clear and involved cavity side margin evaluation. Conclusion: This human study showed the promising role of CDP to achieve clear margins after BCS of neoadjuvant cases. © 2021 John Wiley & Sons Ltd.
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