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Co-Electrospun Poly(Vinyl Alcohol)/Poly(E-Caprolactone) Nanofiber Scaffolds Containing Coffee and Calendula Officinalis Extracts for Wound Healing Applications Publisher



Doostan M1 ; Doostan M1 ; Maleki H2 ; Faridi Majidi R1 ; Bagheri F1 ; Ghanbari H1, 3, 4
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Institute of Biomaterials, University of & University of Medical Sciences, Tehran, Iran

Source: Journal of Bioactive and Compatible Polymers Published:2022


Abstract

Fabrication of a biocompatible nanofibrous dressing with the advantage of the inclusion of bioactive herbal extracts is a promising approach in skin tissue engineering and wound healing applications. Herbal extracts possess many properties to promote the wound healing process, such as antioxidant properties, anti-inflammation activities as well as enhancing fibroblasts proliferation and migration. In this study, Calendula officinalis (C. officinalis) and coffee extracts were loaded into poly(vinyl alcohol)/poly(e-caprolactone) (PVA/PCL) nanofibrous mats. The obtained scaffolds were then characterized using scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR), contact angle, and mechanical measurements. Also, the antioxidant activity, scratch assay, and cell viability of fibroblast cells were also evaluated. The results showed PVA/PCL scaffold loaded with 10 wt% C. officinalis and coffee extracts displayed smooth homogenous morphology with 317 ± 106 nm average diameter. Moreover, the relevant analyses confirmed that the extracts were incorporated into the nanofibers with suitable hydrophilicity and higher mechanical strength (4 ± 0.4 MPa). The antioxidant assay showed that IC50 values of coffee and C. officinalis extracts were 46 ± 1 ppm and 101 ± 4 ppm, successively, which presented a high antioxidant activity. The combination of both extracts showed a higher rate of migration than individual extracts with not detected cytotoxic effects on the human dermal fibroblast cells. In conclusion, our results confirmed that the coffee and C. officinalis extracts loaded PVA/PCL nanofibrous scaffolds could provide an appropriate construct for wound healing applications. © The Author(s) 2022.
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