Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
L. Inermis-Loaded Nanofibrous Scaffolds for Wound Dressing Applications Publisher Pubmed



Vakilian S1, 2 ; Norouzi M1, 3 ; Soufizomorrod M1 ; Shabani I4 ; Hosseinzadeh S5 ; Soleimani M6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Stem Cell Technology Research Center, Tehran, 1997775555, Iran
  2. 2. Laboratory for Stem Cell & Regenerative Medicine, Chair of Oman's Medicinal Plants & Marine Natural Products, University of Nizwa, P. O. Box: 33, Nizwa, 616, PC, Oman
  3. 3. Graduate Program of Biomedical Engineering, University of Manitoba, Winnipeg, MB, Canada
  4. 4. Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, 15875-4413, Iran
  5. 5. School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Hematology, Faculty of Medical Sciences, Tarbiat Modarres University, Tehran, 14115-111, Iran

Source: Tissue and Cell Published:2018


Abstract

Since ancient times, some herbal medicines have been extensively used for burn and wound treatments, showing preference to the common synthetic medications by virtue of having less side effects and faster healing rate. In this study, hybrid nanofibrous scaffolds of poly-L-lactic-acid (PLLA) and gelatin incorporated L. inermis were fabricated via electrospinning technique. Morphology and characteristics of the scaffolds were studied by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR), respectively. The release profile of the L. inermis from the nanofibers was also assessed in vitro. Moreover, the structural stability of the released L. inermis from the nanofibers was evaluated using high-performance liquid chromatography (HPLC). The nanofibers showed a gradual release of L. inermis up to two days while the intact structure was preserved. Furthermore, antibacterial assay demonstrated that L. inermis-loaded nanofibrous scaffolds could effectively kill E. coli and S. aureus within 2 h. Finally, biocompatibility of the nanofibers was proven on 3T3 fibroblasts. Therefore, the L. inermis loaded PLLA-Gelatin nanofibers showed a potential application as a wound dressing in order to control wound infections. © 2018
Related Docs
View other Related Docs
1. Electrospun-Based Systems in Cancer Therapy, Electrospun Materials for Tissue Engineering and Biomedical Applications: Research# Design and Commercialization (2017)
2. Injectable Hydrogel-Based Drug Delivery Systems for Local Cancer Therapy, Drug Discovery Today (2016)
3. A Novel Bilayer Drug-Loaded Wound Dressing of Pvdf and Phb/Chitosan Nanofibers Applicable for Post-Surgical Ulcers, International Journal of Polymeric Materials and Polymeric Biomaterials (2019)
4. In Vitro Fibroblast Migration by Sustained Release of Pdgf-Bb Loaded in Chitosan Nanoparticles Incorporated in Electrospun Nanofibers for Wound Dressing Applications, Artificial Cells# Nanomedicine and Biotechnology (2018)
5. Kaolin-Loaded Chitosan/Polyvinyl Alcohol Electrospun Scaffold As a Wound Dressing Material: In Vitro and in Vivo Studies, Journal of Wound Care (2020)
6. Electrospun Triple-Layered Plla/Gelatin. Prgf/Plla Scaffold Induces Fibroblast Migration, Journal of Cellular Biochemistry (2019)
7. Bioinspired Nanotechnologies for Skin Regeneration, Nanoscience in Dermatology (2016)
8. G-Csf Loaded Nanofiber/Nanoparticle Composite Coated With Collagen Promotes Wound Healing in Vivo, Journal of Biomedical Materials Research - Part A (2017)
Experts (# of related papers)
View all Related Experts
Fatemeh Atyabi (3)
Rassoul Dinarvand (2)
Other Related Docs
9. Study of Epithelial Differentiation and Protein Expression of Keratinocyte-Mesenchyme Stem Cell Co-Cultivation on Electrospun Nylon/B. Vulgaris Extract Composite Scaffold, Materials Science and Engineering C (2017)
10. Controlled Release of Rhegf and Rhbfgf From Electrospun Scaffolds for Skin Regeneration, Journal of Biomedical Materials Research - Part A (2015)
11. Natural Compounds for Skin Tissue Engineering by Electrospinning of Nylon-Beta Vulgaris, ASAIO Journal (2018)
12. Drug Release, Cell Adhesion and Wound Healing Evaluations of Electrospun Carboxymethyl Chitosan/Polyethylene Oxide Nanofibres Containing Phenytoin Sodium and Vitamin C, IET Nanobiotechnology (2015)
13. Poly (Ε-Caprolactone)/Poly (N-Vinyl-2-Pyrrolidone) Core–Shell Nanofibers Loaded by Multi-Walled Carbon Nanotubes and 5-Fluorouracil: An Anticancer Drug Delivery System, Journal of Materials Science (2020)
14. Bioinspired Nanofiber Scaffold for Differentiating Bone Marrow-Derived Neural Stem Cells to Oligodendrocyte-Like Cells: Design, Fabrication, and Characterization, International Journal of Nanomedicine (2020)
15. Mucoadhesive Nanofibrous Membrane With Anti-Inflammatory Activity, Polymer Bulletin (2019)
16. Clinical Applications of Nanomedicine in Cancer Therapy, Drug Discovery Today (2020)
17. Polyethylenimine: A New Differentiation Factor to Endothelial/Cardiac Tissue, Journal of Cellular Biochemistry (2019)
18. Biomimetic Scaffold Containing Pvdf Nanofibers With Sustained Tgf-Β Release in Combination With At-Mscs for Bladder Tissue Engineering, Gene (2018)
19. Overview of Silk Fibroin Use in Wound Dressings, Trends in Biotechnology (2018)
20. Prospects of Sirna Applications in Regenerative Medicine, International Journal of Pharmaceutics (2017)