Impact of Metabolic Syndrome on Clinical Characteristics and One-Year Outcomes of Patients Undergoing Primary Percutaneous Coronary Intervention: A Propensity Score-Matched Comparison Publisher Pubmed



Geraiely B^{1, 4} ; Shahmohamadi E² ; Zare Nejad MJ¹ ; Barzegary A³ ; Larti F⁴ ; Vakilibasir A⁵ ; Haji Zeinali AM¹ Show Affiliations
Source: BMC Cardiovascular Disorders Published:2025

Abstract

Background: Metabolic syndrome (MetS) is a set of symptoms, including insulin resistance, high blood sugar, and abdominal obesity, that increases the risk of cardiovascular diseases. This syndrome is prevalent in acute coronary syndrome (ACS), comprising patients with acute myocardial infarction (AMI). This study evaluated the prognosis of AMI patients who underwent primary PCI in two groups with and without MetS. Methods: This retrospective study was performed on ST-segment elevation myocardial infarction (STEMI) patients referred to the emergency department of Tehran Heart Center from 2012 to 2020 who underwent primary PCI. Patients were divided into MetS and non-MetS according to the International Diabetes Federation (IDF) criteria. Clinical and laboratory characteristics were compared between the two groups. Results: Two thousand, six hundred fifty-one patients were included, and 1850 patients (70%) had MetS. The mean age of patients with MetS compared to non-MetS showed no significant difference (60.16 vs 59.37 years, P-value = 0.053). In both groups, the majority were men. Forty-seven in-hospital deaths occurred, with no significant difference regarding the presence of MetS. Two hundred-six deaths happened during the one-year follow-up, without a significant difference between the two groups. Two hundred-sixteen MACEs were observed in one year, which was not significantly different between patients with and without MetS. Conclusion: In-hospital mortality, one-year death, and one-year MACCE were not associated with MetS in this study. © The Author(s) 2025.