Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Coronavirus Disease 2019 (Covid-19) in Pediatric Patients With Autoimmune Disorders Publisher Pubmed



Sadeghi P1, 2 ; Pezeshki PS2, 3, 4 ; Rezaei N2, 5, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  5. 5. Research Center for Immunodeficiencies, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Dr. Qarib St, Keshavarz Blvd, Tehran, 14194, Iran
  6. 6. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: European Journal of Pediatrics Published:2023


Abstract

Coronavirus disease 2019 (COVID-19) infection in pediatric patients with autoimmune disorders is an area of particular concern since autoimmune diseases can increase the risk of complications from the virus. However, as the infection rates were significantly higher in adults compared to children, this at-risk group of children was relatively underrepresented in COVID-19 research. The underlying inflammatory basis of autoimmune diseases and medications that affect the immune system, such as corticosteroids, could increase the risk of severe infection in this group of patients. COVID-19 could reportedly lead to a variety of alterations in the immune system. These alterations are plausibly dependent on the underlying immune-mediated diseases or prior use of immunomodulatory drugs. Patients administrating immunomodulatory agents, especially those with severe immune system dysregulation, can experience severe symptoms of COVID-19. Nonetheless, receiving immunosuppressive medications can benefit patients by preventing cytokine storm syndromes and lung tissue damage, threatening outcomes of COVID-19. Conclusion: In this review, we sought to evaluate the currently available literature on the impact of autoimmune disease and its related therapeutic approaches on the COVID-19 infection course of disease in children and reflect on the gaps in the evidence and the need for further research in this field.What is Known:What is New: © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Related Docs
View other Related Docs
1. Multisystem Inflammatory Syndrome and Autoimmune Diseases Following Covid-19: Molecular Mechanisms and Therapeutic Opportunities, Frontiers in Molecular Biosciences (2022)
2. Pediatric Endocrinopathies Related to Covid-19: An Update, World Journal of Pediatrics (2023)
3. Covid-19: Our Current Knowledge of Epidemiology, Pathology, Therapeutic Approaches, and Diagnostic Methods, Anti-Cancer Agents in Medicinal Chemistry (2021)
4. Characteristics of Covid-19 in Patients With Multiple Sclerosis, Multiple Sclerosis and Related Disorders (2022)
5. Sars-Cov-2 and Acute Cerebrovascular Events: An Overview, Journal of Clinical Medicine (2021)
6. Pathophysiological Clues to How the Emergent Sars-Cov-2 Can Potentially Increase the Susceptibility to Neurodegeneration, Molecular Neurobiology (2021)
7. Evaluation of the Relationship Between Serum Bdnf Concentration and Indicators of Oxidative Stress and Inflammation in Covid-19 Patients With Neurological Disorders - a Pilot Study, Neurological Research (2023)
8. The Prognostic Value of Comorbidity for the Severity of Covid-19: A Systematic Review and Meta-Analysis Study, PLoS ONE (2021)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (17)
Mohammad Ali Sahraian (7)
Other Related Docs
9. Covid-19 Infection and Stroke Risk, Reviews in the Neurosciences (2021)
10. Pathogenesis, Clinical Manifestations and Complications of Coronavirus Disease 2019 (Covid-19), Future Microbiology (2020)
11. Recent Findings on the Coronavirus Disease 2019 (Covid-19); Immunopathogenesis and Immunotherapeutics, International Immunopharmacology (2020)
12. Can Anti-Parasitic Drugs Help Control Covid-19?, Future Virology (2022)
13. Corona Virus Disease 2019 (Covid-19) As a System-Level Infectious Disease With Distinct Sex Disparities, Frontiers in Immunology (2021)
14. A Review on Currently Available Potential Therapeutic Options for Covid-19, International Journal of General Medicine (2020)
15. The Impact of Covid-19 on Diagnostic Biomarkers in Neuropsychiatric and Neuroimmunological Diseases: A Review, Reviews in the Neurosciences (2022)
16. Characteristics of Children With Kawasaki Disease-Like Signs in Covid-19 Pandemic: A Systematic Review, Frontiers in Pediatrics (2021)
17. Echocardiographic Findings in Multisystem Inflammatory Syndrome in Children (Mis-C) Associated With Covid-19: A Systematic Review, Iranian Journal of Pediatrics (2022)
18. Systematic Review and Meta-Analysis on the Serological, Immunological, and Cardiac Parameters of the Multisystem Inflammatory Syndrome (Mis-C) Associated With Sars-Cov-2 Infection, Journal of Medical Virology (2023)
19. Prophylaxis With Chloroquine and Hydroxychloroquine in Covid-19, Journal of Iranian Medical Council (2020)
20. Covid-19: Neuroimaging Features of a Pandemic, Journal of Neuroimaging (2021)
21. Prevention of Covid-19: Preventive Strategies for General Population, Healthcare Setting, and Various Professions, Advances in Experimental Medicine and Biology (2021)
22. An Algorithmic Approach to Multisystem Inflammatory Syndrome in Children With Covid-19: Tehran Children’S Medical Center Protocol, Iranian Journal of Pediatrics (2020)
23. Cancer Care Management During the Covid-19 Pandemic, Risk Management and Healthcare Policy (2020)
24. Gut Microbiota, Angiotensin-Converting Enzyme, Celiac Disease, and Risk of Covid-19 Infection: A Review, Gastroenterology and Hepatology from Bed to Bench (2021)
25. Anti-Inflammatory Effects of Glp-1 in Patients With Covid-19, Expert Review of Anti-Infective Therapy (2022)
26. Stem Cell Therapy Potency in Personalizing Severe Covid-19 Treatment, Stem Cell Reviews and Reports (2021)
27. A Review on Headaches Due to Covid-19 Infection, Frontiers in Neurology (2022)
28. Sars-Cov-2-Related Mis-C: A Key to the Viral and Genetic Causes of Kawasaki Disease?, Journal of Experimental Medicine (2021)
29. The Outcome of Covid-19 in Patients With a History of Taking Rituximab: A Narrative Review, Iranian Journal of Medical Sciences (2021)
30. The Use of Mesenchymal Stem Cells in the Process of Treatment and Tissue Regeneration After Recovery in Patients With Covid-19, Gene (2021)
31. Prevalence and Outcome of Covid-19 Among Iranian Celiac Patients, Gastroenterology and Hepatology from Bed to Bench (2022)
32. Molecular Signaling Pathways, Pathophysiological Features in Various Organs, and Treatment Strategies in Sars-Cov2 Infection, Acta Histochemica (2022)
33. Clinical Manifestations of Covid-19, Advances in Experimental Medicine and Biology (2021)
34. Sars-Cov-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage, Frontiers in Immunology (2021)
35. Evaluation of the Rate of Covid-19 Infection, Hospitalization and Death Among Iranian Patients With Multiple Sclerosis, Multiple Sclerosis and Related Disorders (2020)
36. Coronavirus Disease 2019 (Covid-19): A Systematic Review of 133 Children That Presented With Kawasaki-Like Multisystem Inflammatory Syndrome, Journal of Medical Virology (2021)
37. The Study of Covid-19 Infection Following Vaccination in Patients With Multiple Sclerosis, Multiple Sclerosis and Related Disorders (2022)
38. The Role of Autophagy in Controlling Sars-Cov-2 Infection: An Overview on Virophagy-Mediated Molecular Drug Targets, Cell Biology International (2021)
39. Autoimmune Complications of Covid-19, Journal of Medical Virology (2022)
40. A Pharmacology-Based Comprehensive Review on Medicinal Plants and Phytoactive Constituents Possibly Effective in the Management of Covid-19, Phytotherapy Research (2021)
41. Covid-19 and Multiorgan Failure: A Narrative Review on Potential Mechanisms, Journal of Molecular Histology (2020)
42. The Prophylaxis and Treatment Potential of Supplements for Covid-19, European Journal of Pharmacology (2020)
43. The Roles of Eph Receptors, Neuropilin-1, P2x7, and Cd147 in Covid-19-Associated Neurodegenerative Diseases: Inflammasome and Jak Inhibitors As Potential Promising Therapies, Cellular and Molecular Biology Letters (2022)
44. Severe Acute Respiratory Syndrome Coronavirus 2 and Seizure: An Insight Into the Pathophysiologic Mechanisms, Current Journal of Neurology (2021)
45. Cranial Nerve Involvement Among Covid-19 Survivors, Frontiers in Neurology (2023)
46. Vaccine Breakthrough Hypoxemic Covid-19 Pneumonia in Patients With Auto-Abs Neutralizing Type I Ifns, Science Immunology (2023)
47. Pharmacological Treatments of Covid-19, Pharmacological Reports (2020)
48. Coronavirus Disease 2019 in Patients With Behcet’S Disease: A Report of 59 Cases in Iran, Clinical Rheumatology (2022)
49. Classification of the Present Pharmaceutical Agents Based on the Possible Effective Mechanism on the Covid-19 Infection, DARU# Journal of Pharmaceutical Sciences (2020)
50. Multisystem Inflammatory Syndrome Associated With Sars-Cov-2 Infection in 45 Children: A First Report From Iran, Epidemiology and Infection (2020)