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Anti-Inflammatory Effects of Glp-1 in Patients With Covid-19 Publisher Pubmed



Sazgarnejad S1, 2, 3 ; Yazdanpanah N1, 3, 4 ; Rezaei N3, 4, 5
Authors
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Authors Affiliations
  1. 1. School Of Medicine, Tehran University Of Medical Sciences, Tehran, Iran
  2. 2. Students’ Scientific Research Center, Tehran University Of Medical Sciences, Tehran, Iran
  3. 3. Network of Immunity in Infection, Malignancy and Autoimmunity (Niima), Universal Scientific Education and Research Network (Usern), Tehran, Iran
  4. 4. Research Center For Immunodeficiencies, Children’s Medical Center, Tehran University Of Medical Sciences, Tehran, Iran
  5. 5. Department Of Immunology, School Of Medicine, Tehran University Of Medical Sciences, Tehran, Iran

Source: Expert Review of Anti-Infective Therapy Published:2022


Abstract

Introduction: Understanding the pathogenesis and risk factors to control the coronavirus disease 2019 (COVID-19) is necessary. Due to the importance of the inflammatory pathways in the pathogenesis of COVID-19 patients, evaluating the effects of anti-inflammatory medications is important. Glucagon-like peptide 1 receptor agonist (GLP-1 RA) is awell-known glucose-lowering agent with anti-inflammatory effects. Areas covered: Resources were extracted from the PubMed database, using keywords such as glucagon-like peptide-1, GLP-1 RA, SARS-CoV-2, COVID-19, inflammation, in April2021. In this review, the effects of GLP-1RA in reducing inflammation and modifying risk factors of COVID-19 severe complications are discussed. However, GLP-1 is degraded by DPP-4 with aplasma half-life of about 2–5 minutes, which makes it difficult to measure GLP-1 plasma level in clinical settings. Expert opinion: Since no definitive treatment is available for COVID-19 so far, determining promising targets to design and/or repurpose effective medications is necessary. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
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