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Effects of Flaxseed Oil Supplementation on Biomarkers of Inflammation and Oxidative Stress in Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Publisher Pubmed



Tamtaji OR1 ; Milajerdi A2 ; Reiner Z3 ; Dadgostar E4 ; Amirani E1 ; Asemi Z1 ; Mirsafaei L5 ; Mansournia MA6 ; Dana PM1 ; Sadoughi F1 ; Hallajzadeh J7
Authors
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Authors Affiliations
  1. 1. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R, Iran
  2. 2. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Internal Medicine, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia
  5. 5. Halal Research Center of IRI, FDA, Tehran, Iran
  6. 6. Department of Cardiology, Ramsar Campus, Mazandaran University of Medical Sciences, Sari, Iran
  7. 7. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Clinical Nutrition ESPEN Published:2020


Abstract

Objective: This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to analyze the effects of flaxseed oil supplementation on biomarkers of inflammation and oxidative stress in patients with metabolic syndrome (MetS) and related disorders. Methods: Databases including PubMed, Scopus, EMBASE, Web of Science, and Cochrane Central library were searched until January 31th, 2019. Results: 14 effect sizes from 12 studies were identified eligible to be included in current meta-analysis. Flaxseed supplementation resulted in a significant reduction in interleukin 6 (IL-6) (WMD: −0.22; 95% CI: −0.43, −0.01) and malondialdehyde (MDA) (WMD: −0.17; 95% CI: −0.31, −0.03) and a significant increase in total antioxidant capacity (TAC) levels (WMD: 137.25; 95% CI: 68.04, 206.47). Flaxseed oil supplementation did not affect other biomarkers of inflammation and oxidative stress. Conclusions: Overall, this meta-analysis demonstrated flaxseed oil supplementation decreased IL-6 and MDA levels, and increased TAC, but did not affect other biomarkers of inflammation and oxidative stress among patients with MetS and related disorders. This suggests that flaxseed oil supplementation may have played an indirect role in improved clinical symptoms in diseases with metabolic disorders. © 2020 European Society for Clinical Nutrition and Metabolism
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