Intensity-Modulated Brachytherapy for Vaginal Cancer

Intensity-Modulated Brachytherapy for Vaginal Cancer Publisher Pubmed

Joya M^{1, 2} ; Nedaie HA¹ ; Geraily G¹ ; Seiri M^{1, 3} ; Ghorbani M⁴ ; Sheikhzadeh P^{1, 5}

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1. Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Radiology Department, Kabul University of Medical Sciences, Kabul, Afghanistan
3. Research Center for Molecular and Cellular Imaging (RCMCI), Advanced Medical Technologies and Equipment Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
4. Biomedical Engineering and Medical Physics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Department of Nuclear Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Source: Radiological Physics and Technology Published:2022

Abstract

This study aimed to evaluate the dose modulation potential of static and dynamic steel-shielded applicators using the Geant4 Application for Emission Tomography (GATE) Monte Carlo code for the treatment of vaginal cancer. The GATE TOOLKIT (version 9.0) was used to simulate vaginal cancer intensity-modulated brachytherapy (IMBT) in a pelvic water-equivalent phantom. IMBT performance of a multichannel static and single-channel dynamic steel-shielded applicator was compared to that of a conventional multichannel Plexiglas applicator. DoseActors were defined to calculate the absorbed dose and attached to the voxelized target and organs at risk (OARs). 60Co and 192Ir high-dose-rate seeds were used as irradiation sources. Dynamic IMBT decreased the D2cc of the rectum and bladder by 28.67 and 28.11% using the 60Co source and by 40.00 and 36.34% using the 192Ir source, respectively. Static IMBT decreased the D2cc for the rectum and bladder by 11.69 and 9.29% using the 60Co source and by 22.21 and 17.71% using the 192Ir source, respectively. In contrast, absorbed dose parameters (D5, D90, and D100) for the target in the three techniques showed a mean relative variation of 0.96% (0.00–7.49%) for both sources. Static and dynamic IMBT using steel-shielded applicators provided relatively better OAR protection while maintaining similar target coverage in the treatment of vaginal cancer. © 2022, The Author(s), under exclusive licence to Japanese Society of Radiological Technology and Japan Society of Medical Physics.

Style	Citing Format
MLA	Joya M, et al.. "Intensity-Modulated Brachytherapy for Vaginal Cancer." Radiological Physics and Technology, vol. 15, no. 4, 2022, pp. 387-397.
APA	Joya M, Nedaie HA, Geraily G, Seiri M, Ghorbani M, Sheikhzadeh P (2022). Intensity-Modulated Brachytherapy for Vaginal Cancer. Radiological Physics and Technology, 15(4), 387-397.
Chicago	Joya M, Nedaie HA, Geraily G, Seiri M, Ghorbani M, Sheikhzadeh P. "Intensity-Modulated Brachytherapy for Vaginal Cancer." Radiological Physics and Technology 15, no. 4 (2022): 387-397.
Harvard	Joya M et al. (2022) 'Intensity-Modulated Brachytherapy for Vaginal Cancer', Radiological Physics and Technology, 15(4), pp. 387-397.
Vancouver	Joya M, Nedaie HA, Geraily G, Seiri M, Ghorbani M, Sheikhzadeh P. Intensity-Modulated Brachytherapy for Vaginal Cancer. Radiological Physics and Technology. 2022;15(4):387-397.
BibTex	@article{ author = {Joya M and Nedaie HA and Geraily G and Seiri M and Ghorbani M and Sheikhzadeh P}, title = {Intensity-Modulated Brachytherapy for Vaginal Cancer}, journal = {Radiological Physics and Technology}, volume = {15}, number = {4}, pages = {387-397}, year = {2022} }
RIS	TY - JOUR AU - Joya M AU - Nedaie HA AU - Geraily G AU - Seiri M AU - Ghorbani M AU - Sheikhzadeh P TI - Intensity-Modulated Brachytherapy for Vaginal Cancer JO - Radiological Physics and Technology VL - 15 IS - 4 SP - 387 EP - 397 PY - 2022 ER -

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