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Evaluating Dose Distributions of High Dose Rate 60Co Brachytherapy in an Asymmetric Tumor: A Comparison of Different Designs of Vaginal Cylindrical Applicators Publisher Pubmed



Aloraibi HA1 ; Siavashpour Z2 ; Ghorbani M3 ; Abtahi M1 ; Jassim H4 ; Gholami S5
Authors
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Authors Affiliations
  1. 1. Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Radiotherapy Oncology Department, Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Biomedical Engineering and Medical Physics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Radiotherapy Physics, General Al-Najaf Hospital, Najaf, Iraq
  5. 5. Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, United States

Source: Applied Radiation and Isotopes Published:2024


Abstract

The aim of this study is to evaluate organ-at-risk (OAR) doses obtained from different designs of intracavitary cylinder applicators during high-dose-rate (HDR) brachytherapy of an asymmetric vaginal tumor. Dose distributions around five cylinder applicators were obtained using the Geant4 toolkit. Three of these applicators are commercially available: single-channel, multi-channel, and shielded. Additionally, two proposed sub-configurations were evaluated: (I) a combination of the multichannel applicator with a central shield and (II) a dynamically modulated cylinder (DMC). The dose distributions of the proposed applicators were compared to those of the single-channel cylinder applicator. The results showed that using a cylindrical applicator with a higher degree of freedom in plan optimization can improve OAR, sparing up to 60% for the rectum and 20% for the bladder. In conclusion, this work suggests using a new design of a cylindrical applicator to enhance the therapeutic ratio of brachytherapy for asymmetric and irregularly shaped vaginal tumors. © 2023 Elsevier Ltd
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