Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effect of Diet Low in Advanced Glycation End Products on Appetite, Body Composition, and Brown Adipose Tissue Markers in Patients With Coronary Artery Disease Treated With Angioplasty: A Randomized Controlled Trial Publisher



Taheri F1 ; Vasheghanifarahani A2 ; Honarkarshafie E1 ; Poorhosseini H3 ; Yaseri M4 ; Hosseinzadehattar M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Hodjat Doost Alley, Naderi St., Keshavarz Blvd, Tehran, Iran
  2. 2. Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Research in Medical Sciences Published:2023


Abstract

Background: Recent changes in dietary habits have resulted in increased intake of advanced glycation end products (AGEs), which are known to have a predominant contribution to the pathogenesis and complications of coronary artery disease (CAD). AGEs are also thought to induce weight gain by affecting appetite, energy expenditure, and brown adipose tissue (BAT). Here, we investigated whether the restriction of dietary AGEs could affect appetite, body composition, anthropometric indices, and BAT-derived markers in CAD patients treated with angioplasty. Materials and Methods: Forty-two stented CAD patients were randomly allocated into two groups that received either a low-AGEs or a control diet for 12 weeks. At baseline and postintervention, fasting blood samples were analyzed for total AGEs, nesfatin-1, and BAT-derived markers (fibroblast growth factor 21 and neuregulin 4). Subjective appetite ratings and body composition were evaluated using the Visual Analog Scale (VAS) and bioelectric impedance analysis. Anthropometric indices, including fat mass index (FMI), abdominal volume index (AVI), and body adiposity index (BAI), were calculated through the relevant formula. Results: Restricting dietary AGEs for 12 weeks could cause a significant reduction in weight, FMI, AVI, and BAI (P < 0.05) compared to the comparison group. In addition, VAS data analyses indicated a significant decrease in the sense of hunger and prospective food intake (P < 0.05) in the intervention group compared to the comparison group. No significant difference was seen in the measured biochemical markers between the two groups. Conclusion: This study indicated that the low-AGEs diet could decrease appetite, weight, and anthropometric indices in stented CAD patients. © 2023 Wolters Kluwer Medknow Publications. All rights reserved.
Related Docs
View other Related Docs
1. Impact of Dietary Advanced Glycation End-Product Restriction on Insulin Resistance and Anthropometric Indices in Coronary Artery Patients Treated With Percutaneous Coronary Intervention: A Randomized Controlled Trial, Journal of Tehran University Heart Center (2023)
2. Advanced Glycation End Products and Risk of Mortality in Patients With Cirrhosis: A Prospective Cohort Study, Scientific Reports (2025)
3. Dietary Advanced Glycation End Products Are Associated With an Increased Risk of Non-Alcoholic Fatty Liver Disease in Iranian Adults, BMC Endocrine Disorders (2023)
4. Association of Different Obesity Indices With Nephrolithiasis in Community-Dwelling Older Adults, Obesity Research and Clinical Practice (2024)
5. The Association Between the Dietary Behavior, Diet Quality, and Lifestyle Scores With Anthropometric Indices and Happiness Levels Among University Students, BMC Nutrition (2024)
6. Optimal Cut-Off Points of Fat Mass Index and Visceral Adiposity Index Associated With Type 2 Diabetes Mellitus, Food Science and Nutrition (2022)
7. Serum and Follicular Fluid Levels of Soluble Receptor for Advanced Glycation End-Products in Women With and Without Polycystic Ovary Syndrome, Journal of Ovarian Research (2023)
8. Effects of Ginger Supplementation on Anthropometric, Glycemic and Metabolic Parameters in Subjects With Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study, Journal of Diabetes and Metabolic Disorders (2019)
Experts (# of related papers)
View all Related Experts
Mohammad Javad Hosseinzadeh Attar (3)
Mehdi Yaseri (2)
Other Related Docs
9. Inflammatory Markers May Mediate the Relationship Between Processed Meat Consumption and Metabolic Unhealthy Obesity in Women: A Cross Sectional Study, Scientific Reports (2023)
10. Dietary Advanced Glycation End Products and Risk of Overall and Cause-Specific Mortality: Results From the Golestan Cohort Study, International Journal of Environmental Research and Public Health (2023)
11. Evaluation of Several Anthropometric and Metabolic Indices As Correlates of Hyperglycemia in Overweight/Obese Adults, Diabetes# Metabolic Syndrome and Obesity (2020)
12. Non-High-Density Lipoprotein Fractions Are Strongly Associated With the Presence of Metabolic Syndrome Independent of Obesity and Diabetes: A Population-Based Study Among Iranian Adults, Journal of Diabetes and Metabolic Disorders (2017)
13. The Association Between Frailty and Body Composition Among the Elderly: Birjand Longitudinal Aging Study (Blas), Journal of Diabetes and Metabolic Disorders (2023)
14. Anthropometric Indices Predicting Incident Hypertension in an Iranian Population: The Isfahan Cohort Study, Anatolian Journal of Cardiology (2019)
15. Implications of the Serum Concentrations of Neuregulin-4 (Nrg4) in Patients With Coronary Artery Disease: A Case-Control Study, Journal of Tehran University Heart Center (2023)
16. A Systematic Review of the Association of Neuregulin 4, a Brown Fat–Enriched Secreted Factor, With Obesity and Related Metabolic Disturbances, Obesity Reviews (2020)