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Natural Killer Cell-Derived Exosomes for Cancer Immunotherapy: Innovative Therapeutics Art Publisher



Hatami Z1 ; Hashemi ZS2 ; Eftekhary M3 ; Amiri A4 ; Karpisheh V5 ; Nasrollahi K6 ; Jafari R7
Authors
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Authors Affiliations
  1. 1. Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  2. 2. ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
  3. 3. Department of Medical Biotechnology, Faculty of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran
  4. 4. Department of Biotechnology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran
  5. 5. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  7. 7. Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran

Source: Cancer Cell International Published:2023


Abstract

Chimeric antigen receptor natural killer cells (CAR-NK) promote off-the-shelf cellular therapy for solid tumors and malignancy.However, the development of CAR-NK is due to their immune surveillance uncertainty and cytotoxicity challenge was restricted. Natural killer cell-derived exosome (NK-Exo) combine crucial targeted cellular therapies of NK cell therapies with unique non-toxic Exo as a self-origin shuttle against cancer immunotherapy. This review study covers cytokines, adoptive (autologous and allogenic) NK immunotherapy, stimulatory and regulatory functions, and cell-free derivatives from NK cells. The future path of NK-Exo cytotoxicity and anti-tumor activity with considering non-caspase-independent/dependent apoptosis and Fas/FasL pathway in cancer immunotherapy. Finally, the significance and implication of NK-Exo therapeutics through combination therapy and the development of emerging approaches for the purification and delivery NK-Exo to severe immune and tumor cells and tissues were discussed in detail. © 2023, BioMed Central Ltd., part of Springer Nature.
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