Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy

Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy Publisher Pubmed

Hosseini R¹ ; Sarvnaz H² ; Arabpour M³ ; Ramshe SM⁴ ; Asefkabiri L⁵ ; Yousefi H⁶ ; Akbari ME⁵ ; Eskandari N¹

Show Affiliations

1. Department of Immunology School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2. Department of Immunology School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Medical Genetics School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Student Research Committee, Department of Medical Genetics, School of Medicine Shahid, Beheshti University of Medical Sciences, Tehran, Iran
5. Surgical Oncologist Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6. Department of Biochemistry and Molecular Biology, LSUHSC School of Medicine, New Orleans, United States

Source: Molecular Cancer Published:2022

Abstract

Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity. As important sentinels of immune surveillance system, natural killer (NK) cells can recognize malignant cells very early and counteract the tumor development and metastasis without a need for additional activation. Based on this rationale, adoptive transfer of ex vivo expanded NK cells/NK cell lines, such as NK-92 cells, has attracted great attention and is widely studied as a promising immunotherapy for cancer treatment. However, by exploiting various strategies, including secretion of exosomes, cancer cells are able to subvert NK cell responses. This paper reviews the roles of TDEs in cancer-induced NK cells impairments with mechanistic insights. The clinical significance and potential approaches to nullify the effects of TDEs on NK cells in cancer immunotherapy are also discussed. © 2022, The Author(s).

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Style	Citing Format
MLA	Hosseini R, et al.. "Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy." Molecular Cancer, vol. 21, no. 1, 2022, pp. -.
APA	Hosseini R, Sarvnaz H, Arabpour M, Ramshe SM, Asefkabiri L, Yousefi H, Akbari ME, Eskandari N (2022). Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy. Molecular Cancer, 21(1), -.
Chicago	Hosseini R, Sarvnaz H, Arabpour M, Ramshe SM, Asefkabiri L, Yousefi H, Akbari ME, Eskandari N. "Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy." Molecular Cancer 21, no. 1 (2022): -.
Harvard	Hosseini R et al. (2022) 'Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy', Molecular Cancer, 21(1), pp. -.
Vancouver	Hosseini R, Sarvnaz H, Arabpour M, Ramshe SM, Asefkabiri L, Yousefi H, et al.. Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy. Molecular Cancer. 2022;21(1):-.
BibTex	@article{ author = {Hosseini R and Sarvnaz H and Arabpour M and Ramshe SM and Asefkabiri L and Yousefi H and Akbari ME and Eskandari N}, title = {Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy}, journal = {Molecular Cancer}, volume = {21}, number = {1}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Hosseini R AU - Sarvnaz H AU - Arabpour M AU - Ramshe SM AU - Asefkabiri L AU - Yousefi H AU - Akbari ME AU - Eskandari N TI - Cancer Exosomes and Natural Killer Cells Dysfunction: Biological Roles, Clinical Significance and Implications for Immunotherapy JO - Molecular Cancer VL - 21 IS - 1 SP - EP - PY - 2022 ER -

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