Antibiotic Susceptibility Patterns of Extended Spectrum Beta-Lactamase and Non Extended Spectrum Beta-Lactamase Pseudomonas Aeruginosa Clinical Isolates Publisher Pubmed



Akbariqomi M^{1, 2} ; Ghafourian S¹ ; Taherikalani M³ ; Mohammadi S¹ ; Pakzad I¹ ; Sadeghifard N¹ Show Affiliations
Source: Recent Patents on Anti-Infective Drug Discovery Published:2015

Abstract

Background: Pseudomonas aeruginosa is known as an opportunistic pathogen responsible for nosocomial infections. Multidrug resistance (MDR) bacteria are considered as a worldwide issue. The current research goal is to investigate the antibiotic susceptibility pattern in Extended Spectrum beta-lactamase and non Extended Spectrum beta-lactamase producing P. aeruginosa clinical isolates. Method: A total of 76 Pseudomonas aeruginosa clinical isolates were collected from Milad hospital in Tehran, Iran, during 8 months period in 2012. P. aeruginosa clinical isolates were subjected for ESBL production by phenotypic methods. The antibiotic susceptibility patterns were identified in ESBL and non-ESBL P. aeruginosa by MIC. Results: our results demonstrated that 76.3% (n =58) isolates were resistant to more than three antibiotics and classified as MDR. The majority of MDR strains were found in ESBL producer P. aeruginosa. ceftazidim as 3rd generation of cephalosporins, ciprofloxacin, Ticarcillin and aztreonam was found as a base for the definition of MDR in the current research. The effective antibiotics against ESBL and non-ESBL were meropenem and amikacin, respectively. Conclusion: based on our knowledge obtained from results, both ESBL and non-ESBL P. aeruginosa were resistant to extended antibiotics and this is a major health care problem. On the other hand, MDR strains were identified in ESBL producer P. aeruginosa. Also, carabapenem resistance was observed in non-ESBL producer strains. Hence, it is recommended that the MDR strains should be followed up. The prescription of ceftazidim, ciprofloxacin, Ticarcillin and aztreonam should be limited. © 2015 Bentham Science Publishers.