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Potential Correlation Between Circulating Fetuin-A and Pentraxin-3 With Biochemical Parameters of Calcification in Hemodialysis Patients Pubmed



Hashemi J1 ; Joshaghani HR2 ; Akaberi A3 ; Hesari Z4 ; Ghanbari R5 ; Mohammadzadeh M1 ; Golshan AR6
Authors
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Authors Affiliations
  1. 1. Emam Ali’s Hospital, North Khorasan University of Medical Sciences, Bojnurd, Iran
  2. 2. School of Paramedicine, Golestan University of Medical Sciences, Gorgan, Iran
  3. 3. Department of Clinical Epidemiology, Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada
  4. 4. Department of Clinical Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran

Source: Archives of Iranian Medicine Published:2017


Abstract

Background: The strong correlation between vascular calcification and cardiovascular risk, which is a major cause of mortality in hemodialysis (HD) patients, has been well established. Fetuin-A is an inhibitor of vascular calcification, and pentraxin 3 (PTX3) is produced at the site of inflammation, which is associated with cardiovascular disease (CVD). The main purpose of this study was evaluating the correlation between fetuin-A and PTX3with some biochemical parameters effective upon vascular calcification in HD patients. Methods: We included 84 HD patients and 84 healthy controls matched for age, gender, and body mass index (BMI) in this study. Blood samples were drawn from all subjects and the serum levels of creatinine, urea, albumin, calcium (Ca), phosphorus (P), low-density lipoprotein cholesterol (LDL-C), parathyroid hormone, fetuin-A, high sensitive C-reactive protein, and PTX3were measured by biochemical methods. Results: We found that the serum levels of PTX3, C-reactive protein (CRP), parathyroid hormone (PTH), Ca, and P in the patient group were significantly higher than the control group but the serum levels of fetuin-A and albumin were significantly lower in the patient group. Also, fetuin-A had a significant correlation with high sensitive CRP (hs-CRP) as well as duration of dialysis. In addition, it was shown that the correlation between PTX3 and PTH was significant only in the patient group. Conclusion: In this study, increased PTX3 and decreased fetuin-A levels were observed in the HD patients. According to our results, these 2 parameters may potentially serve as suitable markers for inflammation and prediction of vascular complications in these patients. © 2017 The Author(s).
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