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Association of Serum Fetuin-A Levels With Allograft Outcome in Renal Transplant Recipients Pubmed



Mehrsai A1 ; Pourmand G1 ; Tehrani HA2 ; Keyhan H2 ; Rahmati MR1 ; Ahmadi A3 ; Dehghani S1 ; Mashhadi R1
Authors
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Authors Affiliations
  1. 1. Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Urology, Bouali Hospital, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
  3. 3. Research Development Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Urology Journal Published:2015


Abstract

Purpose: To determine serum fetuin-A pattern after renal transplantation and its association with graft outcome. Materials and Methods: In 41 renal transplant recipients, serum pretransplant fetuin-A levels and serum fetuin-A concentrations on days 7 and 30 after transplantation were measured using the enzyme-linked immunosorbent assay (ELISA) method. Also, the association between serum fetuin-A levels with clinical and laboratory parameters was evaluated. Results: A significant decrease in serum fetuin-A levels was noted in the first week after transplantation (P < .001). Subsequently, it started to increase and surpass pretransplant values during the first month (P < .001). Pretransplant fetuin-A levels did not differ among patients with different diethylenetriamine pentaacetic acid (DTPA) results. In addition, serum fetuin-A levels did not significantly correlate with metabolic parameters. Conclusion: In this prospective study there was no increase in serum fetuin-A levels during the first month and pretransplant fetuin-A levels are not predictive for allograft outcome in renal transplant recipients.