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The Cortico-Limbo-Thalamo-Cortical Circuits: An Update to the Original Papez Circuit of the Human Limbic System Publisher Pubmed



Kamali A1 ; Milosavljevic S2 ; Gandhi A3 ; Lano KR4 ; Shobeiri P5 ; Sherbaf FG6 ; Sair HI6 ; Riascos RF1 ; Hasan KM1
Authors
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Authors Affiliations
  1. 1. Department of Diagnostic and Interventional Radiology, Neuroradiology Section, University of Texas at Houston, 6431 Fannin St, Houston, 77030, TX, United States
  2. 2. Harvard Medical School, Boston, MA, United States
  3. 3. Baylor College of Medicine Medical School, Houston, TX, United States
  4. 4. McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States
  5. 5. Faculty of Medicine, Tehran University Medical School, Tehran, Iran
  6. 6. Department of Radiology and Radiological Science, Division of Neuroradiology, The Russell H. Morgan, Johns Hopkins University, Baltimore, MD, United States

Source: Brain Topography Published:2023


Abstract

The Papez circuit, first proposed by James Papez in 1937, is a circuit believed to control memory and emotions, composed of the cingulate cortex, entorhinal cortex, parahippocampal gyrus, hippocampus, hypothalamus, and thalamus. Pursuant to James Papez, Paul Yakovlev and Paul MacLean incorporated the prefrontal/orbitofrontal cortex, septum, amygdalae, and anterior temporal lobes into the limbic system. Over the past few years, diffusion-weighted tractography techniques revealed additional limbic fiber connectivity, which incorporates multiple circuits to the already known complex limbic network. In the current review, we aimed to comprehensively summarize the anatomy of the limbic system and elaborate on the anatomical connectivity of the limbic circuits based on the published literature as an update to the original Papez circuit. © 2023, The Author(s).
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