Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Brain Microstructural Abnormalities in Type 2 Diabetes Mellitus: A Systematic Review of Diffusion Tensor Imaging Studies Publisher Pubmed



Sanjari Moghaddam H1 ; Ghazi Sherbaf F1 ; Aarabi MH1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Neuroradiology Division, Tehran University of Medical Sciences, School of Medicine, Tehran, Iran

Source: Frontiers in Neuroendocrinology Published:2019


Abstract

Type 2 diabetes mellitus (T2DM) is associated with deficits in the structure and function of the brain. Diffusion tensor imaging (DTI) is a highly sensitive method for characterizing cerebral tissue microstructure. Using PRISMA guidelines, we identified 29 studies which have demonstrated widespread brain microstructural impairment and topological network disorganization in patients with T2DM. Most consistently reported structures with microstructural abnormalities were frontal, temporal, and parietal lobes in the lobar cluster; corpus callosum, cingulum, uncinate fasciculus, corona radiata, and internal and external capsules in the white matter cluster; thalamus in the subcortical cluster; and cerebellum. Microstructural abnormalities were correlated with pathological derangements in the endocrine profile as well as deficits in cognitive performance in the domains of memory, information-processing speed, executive function, and attention. Altogether, the findings suggest that the detrimental effects of T2DM on cognitive functions might be due to microstructural disruptions in the central neural structures. © 2019 Elsevier Inc.
Related Docs
View other Related Docs
1. White Matter Microstructure in Fetal Alcohol Spectrum Disorders: A Systematic Review of Diffusion Tensor Imaging Studies, Human Brain Mapping (2019)
2. White Matter and Subcortical Gray Matter Microstructural Integrity in Mesial Temporal Lobe Epilepsy: A Combined Diffusion Tensor and Kurtosis Imaging Study, Frontiers in Biomedical Technologies (2020)
3. Involvement of the Left Uncinate Fasciculus in the Amyotrophic Lateral Sclerosis: An Exploratory Longitudinal Multi-Modal Neuroimaging and Neuropsychological Study, Brain Structure and Function (2025)
4. Brain Microstructural Alterations of Depression in Parkinson's Disease: A Systematic Review of Diffusion Tensor Imaging Studies, Human Brain Mapping (2022)
5. The Cortico-Limbo-Thalamo-Cortical Circuits: An Update to the Original Papez Circuit of the Human Limbic System, Brain Topography (2023)
6. Along-Tract Analysis of the White Matter Is More Informative About Brain Ageing, Compared to Whole-Tract Analysis, Clinical Neurology and Neurosurgery (2021)
7. Log-Cholesky Filtering of Diffusion Tensor Fields: Impact on Noise Reduction, Magnetic Resonance Imaging (2024)
8. Clinical and Translational Imaging and Sensing of Diabetic Microangiopathy: A Narrative Review, Journal of Cardiovascular Development and Disease (2023)
Experts (# of related papers)
View all Related Experts
Farzad Fatehi (3)
Seyed Amir Hossein Batouli (3)
Other Related Docs
9. Brain Microstructural Abnormalities in Patients With Wilson’S Disease: A Systematic Review of Diffusion Tenor Imaging Studies, Brain Imaging and Behavior (2022)
10. White Matter Microstructural Changes in Internet Addiction Disorder: A Systematic Review of Diffusion Tensor Imaging Studies, Addictive Behaviors (2023)
11. Saffron As a Promising Therapy for Diabetes and Alzheimer's Disease: Mechanistic Insights, Metabolic Brain Disease (2023)
12. Cardiac Diffusion-Weighted Imaging: From the Physics to Clinical Applications, Research Journal of Medical Sciences (2016)
13. The Involvement of D1 and D2 Dopamine Receptors in the Restoration Effect of Left Frontal Anodal, But Not Cathodal, Tdcs on Streptozocin-Induced Amnesia, Archives of Iranian Medicine (2019)
14. Mediterranean Diet for Active and Healthy Aging, Nutrients and Nutraceuticals for Active and Healthy Ageing (2020)
15. Association of Diabetes Mellitus and Structural Changes in the Central Nervous System in Children and Adolescents: A Systematic Review, Journal of Diabetes and Metabolic Disorders (2017)
16. Simultaneous Increase of Mean Susceptibility and Mean Kurtosis in the Substantia Nigra As an Mri Neuroimaging Biomarker for Early-Stage Parkinson's Disease: A Systematic Review and Meta-Analysis, Journal of Magnetic Resonance Imaging (2025)
17. Main Paths of Brain Fibers in Diffusion Images Mixed With a Noise to Improve Performance of Tractography Algorithm-Evaluation in Phantom, Journal of Biomedical Physics and Engineering (2024)
18. Association Between Pre-Diabetes or Diabetes and Cognitive Impairment in a Community-Dwelling Older Population: Bushehr Elderly Health (Beh) Program, Journal of Diabetes and Metabolic Disorders (2023)
19. Verbal Working Memory-Balance Program Training Alters the Left Fusiform Gyrus Resting-State Functional Connectivity: A Randomized Clinical Trial Study on Children With Dyslexia, Dyslexia (2023)
20. Evaluation of Fronto-Cerebellar Neurometabolites in Youth With Adhd Compared to the Healthy Group and Their Associations With Cognitive and Behavioral Characteristics: A Proton Magnetic Spectroscopy Study, International Journal of Psychophysiology (2022)
21. Anatomo-Functional Profile of White Matter Tracts in Relevance to Language: A Systematic Review, Journal of Neurolinguistics (2024)
22. Extreme Capsule Is a Bottleneck for Ventral Pathway, IBRO Neuroscience Reports (2021)
23. Sequential Language Learning and Language Immersion in Bilingualism: Diffusion Mri Connectometry Reveals Microstructural Evidence, Experimental Brain Research (2017)
24. Crosstalk Between Autophagy and Insulin Resistance: Evidence From Different Tissues, European Journal of Medical Research (2023)
25. Informative Combination of Clu Rs11136000, Serum Hdl Levels, Diabetes, and Age As a New Piece of Puzzle-Picture of Predictive Medicine for Cognitive Disorders, Molecular Biology Reports (2019)
26. Plasma Neurofilament Light Levels Correlate With White Matter Damage Prior to Alzheimer’S Disease: Results From Adni, Aging Clinical and Experimental Research (2022)
27. A Systematic Review of Diffusion Microstructure Imaging (Dmi): Current and Future Applications in Neurology Research, Brain Disorders (2025)
28. Brain Microstructural Abnormalities in 22Q11.2 Deletion Syndrome: A Systematic Review of Diffusion Tensor Imaging Studies, European Neuropsychopharmacology (2021)
29. White Matter Microstructural Associates of Apathy-Avolition in Schizophrenia, Journal of Psychiatric Research (2021)
30. An Improved Model for Prostate Diffusion Incorporating the Results of Monte Carlo Simulations of Diffusion in the Cellular Compartment, NMR in Biomedicine (2017)