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Association Between Metabolic Score for Insulin Resistance and Clinical Outcomes: Insights From the Tehran Lipid and Glucose Study Publisher



Tamehri Zadeh SS1 ; Cheraghloo N2 ; Masrouri S1 ; Esmaeili F1 ; Azizi F3 ; Hadaegh F1
Authors
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Authors Affiliations
  1. 1. Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No. 24, Yamen Street, Velenjak, Tehran, Iran
  2. 2. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Nutrition and Metabolism Published:2024


Abstract

Background: We aimed to assess the relationship between Metabolic Score for Insulin Resistance (METS-IR) and the incidence of coronary heart disease (CHD), stroke, mortality, diabetes, hypertension, and chronic kidney disease (CKD) in a population from the Middle East and North Africa (MENA) region. Method: Individuals aged ≥ 20 years were enrolled. Cox proportional hazards regression models were applied to assess the association between METS-IR and incident CHD, stroke, all-cause mortality, diabetes, hypertension, and CKD. Results: Over a median follow-up period of 9–18 years, 1080 (10.6%), 267 (2.6%), 1022 (9.6%), 1382 (16.4%), 2994 (58.5%), and 2002 (23.0%) CHD, stroke, all-cause mortality, diabetes, hypertension, and CKD events occurred, respectively. Compared to the lowest quartile (reference), the hazard ratios (HR) associated with the highest quartile of METS-IR were 1.527 (95% confidence interval [CI]: 1.208–1.930, P for trend 0.001), 1.393 (0.865–2.243, > 0.05), 0.841 (0.682–1.038, > 0.05), 3.277 (2.645–4.060, < 0.001), 1.969 (1.752–2.214, < 0.001), and 1.020 (0.874–1.191, > 0.05) for CHD, stroke, all-cause mortality, diabetes, hypertension, and CKD, respectively. METS-IR, as a continuous variable, was significantly associated with the risk of incident CHD [HR, 95% CI: 1.106, 1.034–1.184], diabetes [1.524, 1.438–1.616], and hypertension [1.321, 1.265–1.380]. These associations were also independent of metabolic syndrome (METS) and remained unchanged in a subgroup of individuals without METS and/or diabetes. Conclusions: Increasing levels of METS-IR were significantly associated with a greater risk of incident CHD, diabetes, and hypertension; therefore, this index can be a useful tool for capturing the risk of these clinical outcomes. © The Author(s) 2024.
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