Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients

Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients

Farahbakhshfarsi P¹ ; Djazayery A² ; Eshraghian MR³ ; Koohdani F¹ ; Zarei M¹ ; Javanbakht MH¹ ; Derakhshanian H¹ ; Djalali M¹

Show Affiliations

1. Dept. of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
2. Dept. of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
3. Dept. of Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Public Health Published:2016

Abstract

Background: Serum levels of lipocalin 2 (LCN 2) and retinol-binding protein-4 (RBP 4), increase in type 2 diabetes mellitus (T2DM). We sought to determine whether serum LCN 2 and RBP 4 change after an intervention with omega-3 fatty acids supplementation in diabetic patients. Methods: Forty-five type 2 diabetic patients from Iranian Diabetic Association in Tehran, Iran in 2013 were randomly recruited into two groups: one group received 4 g/d omega-3 for 10 wk; and the control group received placebo. Blood samples, food intake records, anthropometric measurements were obtained from all participants at the beginning and end of the study. Results: Fasting RBP 4 plasma levels significantly changed after 10 wk supplementation (P = 0.01). The LCN 2 concentrations decreased in omega-3 group, but the changes were not statistically significant. Omega-3 supplementation had no noticeable effect on anthropometric factors. Conclusions: These findings provide a rationale for omega-3 supplements aimed at lowering serum RBP 4 levels in T2DM. © 2016. Iranian Journal of Public Health. All Right Reserved.

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Style	Citing Format
MLA	Farahbakhshfarsi P, et al.. "Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients." Iranian Journal of Public Health, vol. 45, no. 2, 2016, pp. 179-185.
APA	Farahbakhshfarsi P, Djazayery A, Eshraghian MR, Koohdani F, Zarei M, Javanbakht MH, Derakhshanian H, Djalali M (2016). Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients. Iranian Journal of Public Health, 45(2), 179-185.
Chicago	Farahbakhshfarsi P, Djazayery A, Eshraghian MR, Koohdani F, Zarei M, Javanbakht MH, Derakhshanian H, Djalali M. "Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients." Iranian Journal of Public Health 45, no. 2 (2016): 179-185.
Harvard	Farahbakhshfarsi P et al. (2016) 'Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients', Iranian Journal of Public Health, 45(2), pp. 179-185.
Vancouver	Farahbakhshfarsi P, Djazayery A, Eshraghian MR, Koohdani F, Zarei M, Javanbakht MH, et al.. Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients. Iranian Journal of Public Health. 2016;45(2):179-185.
BibTex	@article{ author = {Farahbakhshfarsi P and Djazayery A and Eshraghian MR and Koohdani F and Zarei M and Javanbakht MH and Derakhshanian H and Djalali M}, title = {Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients}, journal = {Iranian Journal of Public Health}, volume = {45}, number = {2}, pages = {179-185}, year = {2016} }
RIS	TY - JOUR AU - Farahbakhshfarsi P AU - Djazayery A AU - Eshraghian MR AU - Koohdani F AU - Zarei M AU - Javanbakht MH AU - Derakhshanian H AU - Djalali M TI - Effect of Omega-3 Supplementation on Lipocalin 2 and Retinol-Binding Protein 4 in Type 2 Diabetic Patients JO - Iranian Journal of Public Health VL - 45 IS - 2 SP - 179 EP - 185 PY - 2016 ER -

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