Effects of Grape Products on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Publisher Pubmed



Ghalishourani SS¹ ; Farzollahpour F² ; Shirinbakhshmasoleh M³ ; Kolahdouz S³ ; Ghaedi E⁴ ; Behrouzian M⁵ ; Haghighian HK⁶ ; Campbell MS⁷ ; Asbaghi O⁸ ; Moodi V⁹ Show Affiliations
Source: Phytotherapy Research Published:2021

Abstract

This systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted to determine the effects of grapes and grape products on inflammation and oxidative stress among adults. PubMed, Scopus, ISI Web of Science, and Cochrane Library databases were searched up to July 2020 to identify RCTs investigating the effects of grape and grape products on inflammatory and oxidative stress markers. Weighted mean differences (WMD) were pooled using a random-effects model. Of the 8,962 identified studies, 24 RCTs (27 arms) were included in the statistical analysis. Grape products significantly reduced serum C-reactive protein (CRP) levels (WMD: −0.35 mg/L; 95% CI: −0.62, −0.09, p =.008), but they had no significant effect on serum tumor necrosis factor-alpha (TNF-α) (WMD = −1.08 pg/ml; 95% CI: −2.29, 0.11, p =.07), interleukin-6 (IL-6) (WMD = 0.13 pg/ml; 95% CI: −0.35, 0.60, p =.60), total antioxidant capacity (TAC) (WMD = 0.15; 95% CI: −0.35, 0.65, p =.54), or malondialdehyde (MDA) (WMD = 0.14; 95% CI: −0.64, 0.92, p =.72). The analysis indicated possible decreasing effects of grapes and grape products on CRP, but they might not be able to change IL-6, TNF-α, TAC, and MDA concentrations. Nonetheless, further studies are warranted before definitive conclusions may be reached. © 2021 John Wiley & Sons Ltd.