Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association Between Adhering to a Dietary Approach to Stop Hypertension and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis Publisher Pubmed



Abbasi MM1 ; Babaahmadi P2 ; Nozari F3 ; Khosravi F4 ; Golkar Z5 ; Tavasoli Z6 ; Alizadeh V4 ; Nouriani M7 ; Jafari M8 ; Shabani N9 ; Nezhad HH10 ; Soltaninejad H11 ; Rahmanian M12
Authors
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Student Research Committee, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Student Research Committee, School of Dentistry, Islamic Azad University, IAU (Khorasgan Branch), Isfahan, Iran
  7. 7. Babol University of Medical Sciences, Babol, Iran
  8. 8. Universal Scientific Education and Research Network (USERN), Tehran, Iran
  9. 9. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. Student Research Committee, Jondishapoor University of Medical Science, Ahvaz, Iran
  11. 11. Department of Stem Cells Technology and Tissue Regeneration, Faculty of Interdisciplinary Science and Technologies, Tarbiat Modares University, Tehran, Iran
  12. 12. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: BMC Gastroenterology Published:2025


Abstract

Background: Colorectal cancer (CRC) is a high incidence cancer and health problem influenced by many factors emphasizes on the importance of identifying risk factors which can be modified. A dietary approach to stop hypertension (DASH) style promotes a balanced nutrition approach that might have effects on CRC. The aim of this study was to analyze existing evidence on the DASH diet's association with CRC. Methods: Databases, including Scopus, Web of Science, and PubMed, were searched to identify eligible studies up to March 2025. Observational studies investigating the association between adherence to the DASH diet and CRC were included. Effect sizes (ESs) and their confidence intervals (CIs) from fully adjusted models were extracted for the meta-analysis. A random-effects model was employed to calculate the combined ES and assess the relationship between the DASH diet and CRC. The publication bias was assessed using Egger’s test and heterogeneity between studies was examined using the I2 statistic. Results: Fourteen studies were included in this study. Adherence to DASH diet reduced CRC risk (RR = 0.81, 95% CI: 0.73–0.89). Subgroup analyses found consistent effects across cohorts and various factors, with no publication bias. For rectal cancer (RC), adherence to DASH dietary pattern reduced risk of RC (RR = 0.75, 95% CI: 0.66–0.86), particularly in males and cohort studies. Colon cancer risk was also reduced (RR = 0.83, 95% CI: 0.79–0.88), with stronger effects in males and cohort studies. For colorectal adenoma, DASH showed a significant risk reduction (RR = 0.42, 95% CI: 0.22–0.80). Conclusions: Our results highlight that following the DASH diet has a significant effect on lowering the risk of CRC which aligns with previous research. These findings support recommendation of following the DASH diet pattern reduces the burden of CRC. PROSPERO, registration ID: CRD42024569140. © The Author(s) 2025.
Related Docs
View other Related Docs
1. Adherence to the Dietary Approaches to Stop Hypertension (Dash) Dietary Pattern Reduces the Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis, Clinical Nutrition (2020)
2. The Association of Dietary Approaches to Stop Hypertension (Dash) Diet With the Risk of Colorectal Cancer: A Meta-Analysis of Observational Studies, Nutrition and Cancer (2020)
3. Adherence to Dietary Approaches to Stop Hypertension Eating Plan in Relation to Gastric Cancer, Nutrition Journal (2020)
4. Adherence to the Dietary Approaches to Stop Hypertension (Dash) Diet in Relation to All-Cause and Cause-Specific Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Nutrition Journal (2020)
5. Adherence to the Dash Diet and Risk of Breast Cancer, Clinical Breast Cancer (2022)
6. Adherence to the Dietary Approaches to Stop Hypertension (Dash) Diet and Risk of Total and Cause-Specific Mortality: Results From the Golestan Cohort Study, International Journal of Epidemiology (2019)
7. Dietary Approaches to Stop Hypertension and Risk of Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Observational Studies, Clinical Nutrition (2020)
8. Association of Total Nut, Tree Nut, Peanut, and Peanut Butter Consumption With Cancer Incidence and Mortality: A Comprehensive Systematic Review and Dose-Response Meta-Analysis of Observational Studies, Advances in Nutrition (2021)
Experts (# of related papers)
View all Related Experts
Sakineh Shab-Bidar (31)
Ahmad Esmaillzadeh (12)
Other Related Docs
9. Colorectal Cancer: Epidemiology, Risk Factors, and Prevention, Cancers (2024)
10. The Association Between Dash Diet Adherence and Cardiovascular Risk Factors, International Journal of Preventive Medicine (2023)
11. Association of Dietary Approaches to Stop Hypertension Diet and Risk of Bladder Cancer: A Case–Control Study, European Journal of Cancer Care (2022)
12. Healthy and Unhealthy Dietary Patterns and the Risk of Chronic Disease: An Umbrella Review of Meta-Analyses of Prospective Cohort Studies, British Journal of Nutrition (2020)
13. Fruit and Vegetable Intake in Relation to Gastric Cancer Risk: A Comprehensive and Updated Systematic Review and Dose-Response Meta-Analysis of Cohort Studies, Frontiers in Nutrition (2023)
14. The Nordic Diet and the Risk of Non-Communicable Chronic Disease and Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Critical Reviews in Food Science and Nutrition (2022)
15. Impact of Gluten-Free Diet (Gfd) on Some of Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis, Journal of Nutritional Science (2024)
16. Adherence to the Dietary Approaches to Stop Hypertension-Style Diet in Relation to Glioma: A Case-Control Study, British Journal of Nutrition (2016)
17. Adherence to the Dash Diet in Relation to Psychological Profile of Iranian Adults, European Journal of Nutrition (2017)
18. The Association of Dietary Quality Indices and Cancer Mortality: A Systematic Review and Meta-Analysis of Cohort Studies, Nutrition and Cancer (2018)
19. Dietary Approaches to Stop Hypertension (Dash) and Mortality Risk Among Patients With Liver Cirrhosis: A Prospective Cohort Study, BMC Research Notes (2024)
20. Soy Isoflavone Intake and Risk of Cardiovascular Disease in Adults: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Critical Reviews in Food Science and Nutrition (2022)
21. Association Between Obesity and Age-Related Cataract: An Updated Systematic Review and Dose–Response Meta-Analysis of Prospective Cohort Studies, Frontiers in Nutrition (2023)
22. Effect of Low-Fat Diet on Depression Score in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Nutrition Reviews (2025)
23. Diet Quality and Subsequent Incidence of Upper Gastrointestinal Cancers: Results From the Golestan Cohort Study, Archives of Iranian Medicine (2023)
24. Dietary Intake of Tomato and Lycopene, Blood Levels of Lycopene, and Risk of Total and Specific Cancers in Adults: A Systematic Review and Dose–Response Meta-Analysis of Prospective Cohort Studies, Frontiers in Nutrition (2025)
25. Clinical Safety and Efficacy of Bispecific Antibody in the Treatment of Solid Tumors: A Protocol for a Systematic Review, PLoS ONE (2022)
26. Effectiveness of Dry Needling for Improving Pain and Disability in Adults With Tension-Type, Cervicogenic, or Migraine Headaches: Protocol for a Systematic Review, Chiropractic and Manual Therapies (2019)
27. Population Attributable Fraction of Dietary Risk Factors for Cancer Mortality With a Focus on Gastrointestinal Cancers in a Population Based Cohort Study, Scientific Reports (2025)
28. The Association Between Maternal Infection and Intellectual Disability in Children: A Systematic Review and Meta-Analysis, PLoS ONE (2023)
29. Total and Different Dietary Fiber Subtypes and the Risk of All-Cause, Cardiovascular, and Cancer Mortality: A Dose-Response Meta-Analysis of Prospective Cohort Studies, Food and Function (2023)
30. The Association Between Dietary Inflammatory Potential and Risk of Total and Site-Specific Colorectal Cancer: A Systematic Review and Meta-Analysis of Observational Studies, British Journal of Nutrition (2025)
31. Adherence to the Mediterranean Diet in Relation to All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies, Advances in Nutrition (2019)
32. Alcohol Consumption and Frailty Risk: A Dose–Response Meta-Analysis of Cohort Studies, Age and Ageing (2024)
33. The Effect of Algae Supplementation on Anthropometric Indices in Adults: A Grade-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials, Nutrition Reviews (2025)
34. Adherence to the Dietary Approaches to Stop Hypertension-Style Diet Is Inversely Associated With Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies, Nutrition Research (2019)
35. The Relationship Between Dietary Patterns, Dietary Quality Index, and Dietary Inflammatory Index With the Risk of All Types of Cancer: Golestan Cohort Study, Medical Journal of the Islamic Republic of Iran (2021)
36. Interactions Between Dash-Style Diet and Adipoq and Arl15 Genes Polymorphisms on Blood Pressure and Central Obesity in Iranian Adults, Scientific Reports (2025)
37. Role of Dietary Approaches to Stop Hypertension Diet in Risk of Metabolic Syndrome: Evidence From Observational and Interventional Studies, International Journal of Preventive Medicine (2021)
38. The Effects of Purslane (Portulaca Oleracea) on Glycemic Indices: A Grade-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials, Phytotherapy Research (2023)
39. The Relationship Between Dietary Approaches to Stop Hypertension Diet Adherence and Inflammatory Factors and Insulin Resistance in Overweight and Obese Women: A Cross-Sectional Study, Diabetes Research and Clinical Practice (2021)
40. Daily Step Count and All-Cause Mortality: A Dose–Response Meta-Analysis of Prospective Cohort Studies, Sports Medicine (2022)
41. A Systematic Review of the Effects of Ketogenic Diet on Treatment Outcomes and Quality of Life in Breast Cancer Patients, Iranian Journal of Obstetrics# Gynecology and Infertility (2023)
42. Impact of Melatonin Supplementation on Glycemic Parameters in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis, Current Pharmaceutical Design (2025)
43. Soluble Fiber Supplementation and Serum Lipid Profile: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials, Advances in Nutrition (2023)
44. Crocin Supplementation on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis, Phytotherapy Research (2025)
45. The Effects of Lifestyle Modifications Including Dietary and Physical Interventions With Cognitive-Behavioral Therapy on Quality of Life and Cancer-Recurrence Rate Among Patients With Breast Cancer and Survivors: A Protocol for a Systematic Review and Meta-Analysis of Randomized Controlled Trial, International Journal of Cancer Management (2020)
46. Pharmacological Therapies for Management of Opium Withdrawal, Cochrane Database of Systematic Reviews (2018)
47. Association Between Adherence to the Mediterranean Diet and Risk of Type 2 Diabetes: An Updated Systematic Review and Dose–Response Meta-Analysis of Prospective Cohort Studies, Advances in Nutrition (2022)
48. Food Addiction and Binge Eating Disorder in Relation to Dietary Patterns and Anthropometric Measurements: A Descriptive-Analytic Cross-Sectional Study in Iranian Adults With Obesity, Behavioral Medicine (2024)
49. Per-And Poly-Fluoroalkyl Substances (Pfas) Exposure and Risk of Kidney, Liver, and Testicular Cancers: A Systematic Review and Meta-Analysis, Medicina del Lavoro (2023)
50. Dietary Glycemic Index, Glycemic Load, and Chronic Disease: An Umbrella Review of Meta-Analyses of Prospective Cohort Studies, Critical Reviews in Food Science and Nutrition (2022)