Long-Term Protection Against the Hepatitis B Virus Detected Through an Early Response to a Booster Dose Injection

Long-Term Protection Against the Hepatitis B Virus Detected Through an Early Response to a Booster Dose Injection Publisher Pubmed

Saffar H¹ ; Khalilian AR² ; Saffar MJ³ ; Ajami A⁴

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1. Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Biostatistics, Mazandaran University of Medical Sciences, Sari, Iran
3. Pediatric Infectious Diseases Ward and Antimicrobial Resistance Nosocomial Infection Research Center, Mazandaran University of Medical Sciences, Sari, Iran
4. Immunology and Molecular and Cellular Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran

Source: Indian Pediatrics Published:2018

Abstract

Objective: To determine the duration of protection conferred by the hepatitis B (HB) vaccination and the necessity of a booster dose. Methods: Immediately after the initial blood sampling, 252 youths (aged 18.8-20.5 years, 52% females) with a history of neonatal HB vaccination with one dose of the HB vaccine received a booster. Serum concentrations of antibodies against the HB surface antigen were assessed in samples collected before and 10-14 days after the booster. Seroconversion from concentrations <10 to ≥10 IU/L were defined as a positive immune response. Results: Of the 252 participants, 131 were serosusceptible and 114 responded. Conclusions: Nearly 90% of young people preserved their long-term protection; the results of this study do not support the use of an HB booster vaccination. © 2018, Indian Academy of Pediatrics.

2. Immune Responses to Hepatitis B Immunization 10–18 Years After Primary Vaccination: A Population-Based Cohort Study, Journal of Viral Hepatitis (2016)

3. Coverage and Long-Term Immunogenicity of Hepatitis B Vaccine in Healthcare Workers, Archives of Clinical Infectious Diseases (2016)

4. Effect of Tetanus-Diphtheria Vaccine on Immune Response to Hepatitis B Vaccine in Low-Responder Individuals, International Journal of Preventive Medicine (2016)

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Style	Citing Format
MLA	Saffar H, et al.. "Long-Term Protection Against the Hepatitis B Virus Detected Through an Early Response to a Booster Dose Injection." Indian Pediatrics, vol. 55, no. 1, 2018, pp. 45-47.
APA	Saffar H, Khalilian AR, Saffar MJ, Ajami A (2018). Long-Term Protection Against the Hepatitis B Virus Detected Through an Early Response to a Booster Dose Injection. Indian Pediatrics, 55(1), 45-47.
Chicago	Saffar H, Khalilian AR, Saffar MJ, Ajami A. "Long-Term Protection Against the Hepatitis B Virus Detected Through an Early Response to a Booster Dose Injection." Indian Pediatrics 55, no. 1 (2018): 45-47.
Harvard	Saffar H et al. (2018) 'Long-Term Protection Against the Hepatitis B Virus Detected Through an Early Response to a Booster Dose Injection', Indian Pediatrics, 55(1), pp. 45-47.
Vancouver	Saffar H, Khalilian AR, Saffar MJ, Ajami A. Long-Term Protection Against the Hepatitis B Virus Detected Through an Early Response to a Booster Dose Injection. Indian Pediatrics. 2018;55(1):45-47.
BibTex	@article{ author = {Saffar H and Khalilian AR and Saffar MJ and Ajami A}, title = {Long-Term Protection Against the Hepatitis B Virus Detected Through an Early Response to a Booster Dose Injection}, journal = {Indian Pediatrics}, volume = {55}, number = {1}, pages = {45-47}, year = {2018} }
RIS	TY - JOUR AU - Saffar H AU - Khalilian AR AU - Saffar MJ AU - Ajami A TI - Long-Term Protection Against the Hepatitis B Virus Detected Through an Early Response to a Booster Dose Injection JO - Indian Pediatrics VL - 55 IS - 1 SP - 45 EP - 47 PY - 2018 ER -

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