High Prevalence of Occult Hepatitis B Infection (Obi) Among Healthy Children and Their Parents in Alborz Province, Iran; Vertical Obi, Myth or Truth?

High Prevalence of Occult Hepatitis B Infection (Obi) Among Healthy Children and Their Parents in Alborz Province, Iran; Vertical Obi, Myth or Truth? Publisher Pubmed

Ghaziasadi A¹ ; Fakhari Z² ; Aghcheli B¹ ; Poortahmasebi V^{3, 4, 5} ; Farahmand M¹ ; Norouzi M^{1, 5} ; Ghalichi L⁶ ; Soleimani A⁷ ; Hedayat Yaghoobi M⁷ ; Ravanshad M² ; Jazayeri SM^{1, 5}

Show Affiliations

1. Department of Virology, School of Public Health, Tehran University of Medical Sciences Tehran, Tehran, Iran
2. Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
3. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4. Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
5. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
6. Mental Health Research Center, Psychosocial Health Research Institute, Iran University of Medical Sciences Tehran, Tehran, Iran
7. Department of Infectious Disease, Imam Ali Hospital, Alborz University of Medical Sciences, Karaj, Iran

Source: Liver International Published:2020

Abstract

Background: Occult hepatitis B infection (OBI) has been described in various clinical settings including after hepatitis B virus (HBV) immunization. The purpose of study was to characterize the prevalence of OBI among immunized children from a subset of general population and the parents of OBI-positive cases. Methods: Sera of 1200 children from general population who have been previously immunized by HBV vaccine were assayed for anti-HBs. 660 were randomly selected for HBV DNA testing by different polymerase chain reaction (PCR) methods and were analysed by direct sequencing on surface genes. Results: None of participants were positive for HBsAg and anti-HBc. 549 (45.7%) and 651 (54.3%) cases had anti-HBs > 10 mIU/mL (responders) and < 10 mIU/mL (nonresponders) respectively. Of 660 selected specimens, 91 (16%) of children were positive for OBI. 23 (25.2%) and 68 (74.8%) of HBV DNA positive cases were belonged to responders and nonresponders, respectively, showing significant difference (P <.001). The mean levels of anti-HBs in OBI-positive and OBI-negative groups, showed no considerable variations. The mean viral load for OBI-positive cases showed substantial differences between responders and nonresponders (P =.007). Of 49 parents (98 individuals) of OBI-positive children 11 (22%) and 18 (36%) were positive for anti-HBc and anti-HBs respectively. Molecular testing was positive in 32 subjects (16 couples, 32.6%). In total, 6 mothers and 11 fathers were positive for OBI. Conclusion: A proportion of OBI-positive vaccinated children could be existed in different populations. This finding could be arisen from vertical HBV transmission or vertical OBI possibly from their parents. © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

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Seyed Mohammad Jazayeri (11)

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Style	Citing Format
MLA	Ghaziasadi A, et al.. "High Prevalence of Occult Hepatitis B Infection (Obi) Among Healthy Children and Their Parents in Alborz Province, Iran; Vertical Obi, Myth or Truth?." Liver International, vol. 40, no. 1, 2020, pp. 92-100.
APA	Ghaziasadi A, Fakhari Z, Aghcheli B, Poortahmasebi V, Farahmand M, Norouzi M, Ghalichi L, Soleimani A, Hedayat Yaghoobi M, Ravanshad M, Jazayeri SM (2020). High Prevalence of Occult Hepatitis B Infection (Obi) Among Healthy Children and Their Parents in Alborz Province, Iran; Vertical Obi, Myth or Truth?. Liver International, 40(1), 92-100.
Chicago	Ghaziasadi A, Fakhari Z, Aghcheli B, Poortahmasebi V, Farahmand M, Norouzi M, Ghalichi L, et al.. "High Prevalence of Occult Hepatitis B Infection (Obi) Among Healthy Children and Their Parents in Alborz Province, Iran; Vertical Obi, Myth or Truth?." Liver International 40, no. 1 (2020): 92-100.
Harvard	Ghaziasadi A et al. (2020) 'High Prevalence of Occult Hepatitis B Infection (Obi) Among Healthy Children and Their Parents in Alborz Province, Iran; Vertical Obi, Myth or Truth?', Liver International, 40(1), pp. 92-100.
Vancouver	Ghaziasadi A, Fakhari Z, Aghcheli B, Poortahmasebi V, Farahmand M, Norouzi M, et al.. High Prevalence of Occult Hepatitis B Infection (Obi) Among Healthy Children and Their Parents in Alborz Province, Iran; Vertical Obi, Myth or Truth?. Liver International. 2020;40(1):92-100.
BibTex	@article{ author = {Ghaziasadi A and Fakhari Z and Aghcheli B and Poortahmasebi V and Farahmand M and Norouzi M and Ghalichi L and Soleimani A and Hedayat Yaghoobi M and Ravanshad M and Jazayeri SM}, title = {High Prevalence of Occult Hepatitis B Infection (Obi) Among Healthy Children and Their Parents in Alborz Province, Iran; Vertical Obi, Myth or Truth?}, journal = {Liver International}, volume = {40}, number = {1}, pages = {92-100}, year = {2020} }
RIS	TY - JOUR AU - Ghaziasadi A AU - Fakhari Z AU - Aghcheli B AU - Poortahmasebi V AU - Farahmand M AU - Norouzi M AU - Ghalichi L AU - Soleimani A AU - Hedayat Yaghoobi M AU - Ravanshad M AU - Jazayeri SM TI - High Prevalence of Occult Hepatitis B Infection (Obi) Among Healthy Children and Their Parents in Alborz Province, Iran; Vertical Obi, Myth or Truth? JO - Liver International VL - 40 IS - 1 SP - 92 EP - 100 PY - 2020 ER -

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