Tehran University of Medical Sciences

Science Communicator Platform

Share By
Triglyceride-Glucose Index As a Predictor of Body Composition Changes in Patients Undergoing Bariatric Surgery Publisher



Hazaveh M M ; Shojaei S ; Mousavi A ; Zooravar D ; Aghamohamadpour S ; Yousefifar S ; Talebpour M ; Radkhah H
Authors

Source: Journal of Diabetes and Metabolic Disorders Published:2026


Abstract

Background: The triglyceride-glucose index (TyG) is a practical marker for assessing insulin resistance. This study evaluates the ability of the TyG index to predict body composition changes in patients following bariatric surgery. Methods: A retrospective cohort study of 190 participants (45 diabetics, 89 pre-diabetics, and 56 normal glycemic) undergoing bariatric surgery at Sina Hospital from 2024 to 2025 was conducted. Body composition was measured via bioelectrical impedance analysis (BIA) at baseline, 3- and 6-months post-surgery. The main outcome was the association between baseline TyG levels and changes in body composition. Subgroup analyses were performed based on glycemic status. Results: Among diabetics, baseline TyG negatively correlated with free fat mass (rho=-0.427, p = 0.005), basal metabolic rate (rho=-0.733, p = 0.002), and total body water (rho=-0.441, p = 0.005) at 3-months post-surgery. Pre-diabetic and normoglycemic participants showed similar negative associations between baseline TyG and fat mass changes at 3 months (rho=-0.250, p = 0.023 and rho=-0.348, p = 0.011) and 6 months (rho=-0.228, p = 0.036 and rho=-0.436, p = 0.002) post-surgery. Weight and body mass index also demonstrated significant negative correlations with baseline TyG. Additionally, TyG index significantly decreased at both 3- and 6-months across all subgroups. Conclusion: The TyG index appears to be a useful predictor of body composition changes after bariatric surgery, particularly among patients with diabetes. The significant alterations observed in the TyG index within the first 3- and 6- months post-surgery suggest its potential as a marker of metabolic health in bariatric interventions. © The Author(s), under exclusive licence to Tehran University of Medical Sciences 2026.
Related Docs
View other Related Docs
1. Prevalence of Metabolically Healthy Obesity and Healthy Overweight and the Associated Factors in Southern Iran: A Population-Based Cross-Sectional Study, Health Science Reports (2024)
2. Exploring the Tyg Index and the Homeostasis Model Assessment of Insulin Resistance As Insulin Resistance Markers: Implications for Fibromyalgia Management and Understanding—A Narrative Review, Diagnostics (2025)
3. Predictive Value of Complete Blood Count (Cbc)-Derived Indices—C-Reactive-Protein-Albumin-Lymphocyte Index (Cally), Glucose-To-Lymphocyte Ratio (Glr), Prognostic Nutritional Index (Pni), Hemoglobin, Albumin, Lymphocyte, Platelet (Halp), and Controlling Nutritional Status (Count)—On Body Composition Changes After Bariatric Surgery, Obesity Surgery (2025)
Experts (# of related papers)
View all Related Experts
Bagher Larijani (3)
Sakineh Shab-Bidar (2)
Other Related Docs
4. Validity of Triglyceride–Glucose Index As an Indicator for Metabolic Syndrome in Children and Adolescents: The Caspian-V Study, Eating and Weight Disorders (2018)
5. Levels and Trends of Bmi, Obesity, and Overweight at National and Sub-National Levels in Iran From 1990 to 2016; a Comprehensive Pooled Analysis of Half a Million Individuals, Archives of Iranian Medicine (2021)
6. Waist-To-Hip Ratio As a Contributor Associated With Higher Atherosclerotic Cardiovascular Disease Risk Assessment in Patients With Diabetes: A Cross-Sectional Study, BMC Cardiovascular Disorders (2024)
7. Shared Lifestyle-Related Risk Factors of Cardiovascular Disease and Cancer: Evidence for Joint Prevention, Scientific World Journal (2023)
8. The Association Between Meal-Based Diet Quality Index-International (Dqi-I) With Obesity in Adults, BMC Nutrition (2022)
9. Triglyceride-Glucose Index and Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis, Lipids in Health and Disease (2024)
10. The Association of Plant-Based Dietary Patterns With Visceral Adiposity, Lipid Accumulation Product, and Triglyceride-Glucose Index in Iranian Adults, Complementary Therapies in Medicine (2020)
11. Investigating the Association Between the Triglyceride-Glucose Index and Peripheral Artery Disease: A Systematic Review and Meta-Analysis, Nutrition and Diabetes (2024)
12. Mediterranean Dietary Quality Index and Dietary Phytochemical Index Among Patients Candidate for Coronary Artery Bypass Grafting (Cabg) Surgery, BMC Cardiovascular Disorders (2017)
13. Obesity in Covid-19 Era, Implications for Mechanisms, Comorbidities, and Prognosis: A Review and Meta-Analysis, International Journal of Obesity (2021)
14. The Association Between Healthy Beverage Index and Healthy and Unhealthy Obesity Phenotypes Among Obese Women: A Cross-Sectional Study, Genetics Research (2022)
15. Effect of Survodutide, a Glucagon and Glp-1 Receptor Dual Agonist, on Weight Loss: A Meta-Analysis of Randomized Controlled Trials, Diabetology and Metabolic Syndrome (2024)
16. Investigating the Obesity Trend of Overweight and Obese People With Pictograms Among Iranian Adults, Journal of Diabetes and Metabolic Disorders (2025)
17. Water Intake and Intra-Meal Fluid Consumption in Relation to General and Abdominal Obesity of Iranian Adults, Nutrition Journal (2020)
18. Association of Triglyceride-Glucose Index With Bone Mineral Density and Fracture: A Systematic Review, Diabetology and Metabolic Syndrome (2025)
19. The Global Syndemic of Obesity, Undernutrition, and Climate Change: The Lancet Commission Report, The Lancet (2019)
20. Association Between Triglyceride-Glucose Index and Coronary Artery In-Stent Restenosis: A Case-Control Study in an Iranian Patient Population, ARYA Atherosclerosis (2026)