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One Anastomosis Gastric Bypass Surgery in Type2 Diabetes Patients With Body Mass Index < 35 Kg/M2: A Multi-Center Retrospective Cohort Study Publisher



Amirbeigi A1, 2 ; Abbaslou F3 ; Talebpour M4 ; Soroush A5, 6, 7 ; Elyasinia F5 ; Zabihi Mahmoudabadi H4 ; Najjari K4
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Authors Affiliations
  1. 1. Department of General Surgery, School of Medicine, Kerman University of Medical, Iran
  2. 2. Clinical Research Development Unit, Shahid Bahonar Hospital, Kerman University of Medical Sciences, Kerman, Iran
  3. 3. Department of Obstetrics and Gynecology, Mirza Kuchekkhan Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of General Surgery, Sina Hospital Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of General Surgery, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Obesity and Eating Habits Research Center, Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Annals of Medicine and Surgery Published:2022


Abstract

Introduction: Bariatric surgeries have shown efficacy in weight reduction, glycemic control and improvement of type-2 diabetes (T2DM) in patients with obesity. We aimed to assess the efficacy of one anastomosis gastric bypass surgery (OAGB) in T2DM patients with body mass index (BMI) < 35 kg/m2 within a year after surgery. Methods: In this multicenter retrospective cohort study, 14 T2DM patients with BMI <35 kg/m2 (females, %: 71.4% (10 of 14), and age, mean (standard deviation): 51.2 (12.3) years) who had underwent OAGB surgery by the same surgeon, were followed at intervals of one, three, six, and 12 months after surgery. The remission rates of T2DM were calculated and the metabolic indices were compared using paired t-test and Wilcoxon rank test. Results: No adverse outcomes were detected 12 months after surgery. Within six months, seven (50%) patients underwent remission (one (7.1%) within one, three (21.4%) within three, and three (21.4%) within six months). Post-operative weight (p < 0.001) and fasting blood glucose (p < 0.01) in all time periods were significantly lower compared to pre-operative values. Hemoglobin A1C (HbA1C) was significantly lower at three- and six-month intervals (p < 0.05) but not at twelve months (p = 0.2). Thyroid-stimulating hormone and triglyceride levels were lower at six months compared to pre-surgical levels (p < 0.05) but cholesterol levels were not different in any of time points (p > 0.05). Conclusion: OAGB surgery is associated with weight reduction, glycemic control and a 50% remission rate within six months in patients with diabetes and BMI <35 kg/m2. © 2022
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