The Expression of Sox10 and Its Value for Predicting Tumor Biological Behaviors in Patients Suffering Gastric Adenocarcinoma, Cross Sectional Study Publisher



Miratashi Yazdi SA¹ ; Nazar E² ; Shafiei S² Show Affiliations
Source: International Journal of Surgery Open Published:2022

Abstract

Background: Special attention has been recently paid to the expression of the SOX10 marker, which is actually responsible for coordinating the signaling process of the Wnt/B-catenin evolutionary pathway and therefore responsible for cell proliferation and differentiation in tumor cells. We aimed to study the expression of this marker in different types of gastric adenocarcinomas and to find its relationship with histopathologic features of the tumor. Methods: This cross-sectional study was performed on patients with gastric adenocarcinoma (diffuse or intestinal type) whose malignancy could be confirmed by tissue. Subjects were classified according to CAP criteria based on pathology results. Patients underwent immunohistochemical staining to evaluate SOX10 expression. Tumor behavior was determined based on histological studies. Results: SOX10 positivity was reported in 22.5% of all tissue samples assessed. The assessment of relationship between SOX10 expression and baseline and tumor characteristics showed no significant association of SOX10 expression and patients’ gender, age, tumor location, tumor size, its type and also lymphovascular and perineural invasions. Conclusion: The expression of the SOX10 marker is expected only in 22.5% of patients diagnosed with gastric cancer. In our society, the expression of this marker has nothing to do with the biological and aggressive behaviors of this tumor. © 2022