The Value of Sox10 Expression in Predicting Perineural Invasion in Gastric Cancer; [El Valor De La Expresion De Sox10 En La Prediccion De La Invasion Perineural En El Cancer Gastrico] Publisher Pubmed



Yazdi SAM¹ ; Moghtadaie A² ; Nazar E³ Show Affiliations
Source: Revista Espanola de Patologia Published:2023

Abstract

Background: SRY-related HMG-box 10 (SOX10) protein has a confirmed role in the regulation of neural cell proliferation and differentiation. It is now suggested that the changes in SOX10 expression may be linked to neural invasion by cancer cells. We aimed to assess the value of SOX10 expression in predicting perineural invasion in gastric cancer. Methods: A cross-sectional study was performed on 40 patients with gastric cancer. To assess perineural invasion, Hematoxylin & Eosin stained slides were examined. The expression of SOX10 was also examined by immunohistochemistry. Results: Our study showed higher perineural invasion in those with SOX10 positivity as compared to those without SOX10 expression (64.0% vs. 6.7%, p = 0.001). No association was revealed between other baseline variables and SOX10 positivity. The expression of this marker increased the chance of neural invasion up to 17 times as indicated by the multivariable regression modeling. Multivariable regression modeling indicated that the chance of neural invasion increased up to 17 times in cases of SOX10 positivity. Conclusion: Overexpression of SOX10 is closely associated with the risk of perineural invasion in gastric cancer. © 2023 Sociedad Espanola de Anatomia Patologica